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What's new in PrEP research and advocacy? Click on the links below!

-- Methodological Challenges in Biomedical HIV Prevention Trials
Institute of Medicine (IOM)
21 February 2008
In 2007, the IOM convened a meeting to discuss how to improve the methodology, design, and conduct of HIV prevention trials, focusing on microbicide and pre-exposure prophylaxis (PrEP) trials, in order to increase their likelihood of success and to enable donors to optimally invest resources. This is a report of that meeting and discusses various ways to improve the design, monitoring, and analysis of late-stage randomized clinical trials of biomedical interventions to prevent HIV infection....click here to read more

-- Perspectives: Antiretroviral Therapy for Prevention of HIV Infection: New Clues From an Animal Model
PLoS Medicine
5 February 2008
This Perspectives piece discusses the new study published in PLoS Medicine, "Prevention of Rectal SHIV Transmission in Macaques by Daily or Intermittent Prophylaxis with Emtricitabine and Tenofovir."
click here to read

-- Prevention of Rectal SHIV Transmission in Macaques by Daily or Intermittent Prophylaxis with Emtricitabine and Tenofovir
PLoS Medicine
5 February 2008
PrEP has never been shown to be effective against sexual transmission of HIV in humans. Studies of PrEP in people at risk for HIV are currently in progress or being planned, but it is not clear which medications or dosing schedules should be used. The researchers in this study wanted to explore several possible ways of giving PrEP in monkeys in order to learn more about how to design strategies for testing PrEP in humans....click here to read more

-- Antiretroviral Pre-exposure Prophylaxis Prevents Vaginal Transmission of HIV-1 in Humanized BLT Mice
PLoS Medicine
14 January 2008
Worldwide, vaginal transmission now accounts for more than half of newly acquired HIV-1 infections. Despite the urgency to develop and implement novel approaches capable of preventing HIV transmission, this process has been hindered by the lack of adequate small animal models for preclinical efficacy and safety testing. Given the importance of this route of transmission, we investigated the susceptibility of humanized mice to intravaginal HIV-1 infection....click here to read more

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