Global Guidance

Global guidance helps set expectations, define priorities and can pave the way for national action.


For quick facts on WHO's updated PrEP recommendation, click here.

For the full report, click below.
Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection — Second edition
In June 2016, WHO released guidelines on the diagnosis of HIV infection, the use of ARVs for treating and preventing HIV infection and the care of people living with HIV. They are structured along the continuum of HIV testing, prevention, treatment and care. This edition updates the 2013 consolidated guidelines on the use of antiretroviral drugs following an extensive review of evidence and consultations in mid-2015.

Oral Pre-Exposure Prophylaxis–Putting a New Choice in Context
This 2015 publication, produced collaboratively between UNAIDS, WHO and AVAC, is intended to complement forthcoming WHO recommendations and support the optimal use of oral PrEP to protect individuals and contribute to ending the AIDS epidemic.

Recommendations on the Use of Daily oral PrEP for All Populations – PEPFAR Scientific Advisory Board (SAB)
Created in late 2015 by PEPFAR’s PrEP Expert Working Group for the PEPFAR Scientific Advisory Board, this report explores the logistics, support and priorities needed for PEPFAR-funded programs to successfully implement PrEP.

Consolidated Guidelines on HIV Prevention, Diagnosis, Treatment and Care for Key Populations
In 2014, WHO updated its Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection to include a recommendation of PrEP as a prevention option for gay men and other men who have sex with men; this document also recognizes the utility of PrEP for serodiscordant couples in some contexts.

PrEP Demonstration Projects: A Framework for Country Level Protocol Development
Issued by the World Health Organization in 2013.

Guidance on Pre-Exposure Oral Prophylaxis (PrEP) for Serodiscordant Couples, Men and Transgender Women Who Have Sex with Men at High Risk of HIV
Issued by the World Health Organization in 2012.

This page will be updated as additional global guidance and decision-maker tools are developed and disseminated by WHO and UNAIDS.

News Spotlight

  • A Daily Pill Can Prevent HIV Infections. Why Don’t More People Use It?

    March 9, 2018

    There’s no question that a simple regimen of a single daily pill can slash HIV infections in people at risk. But although millions of people around the world could benefit, only 200,000 are prescribed PrEP, and 75 percent of them are in the United States. The disparity was the focus of anguished discussions this week at the largest annual US HIV/AIDS conference.

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  • Mapping PrEP: First ever data on PrEP users across the US

    March 6, 2018

    The Center for AIDS Research at Emory University's Rollins School of Public Health produces interactive online maps with visualized data on different aspects of the US HIV epidemic, and its prevention and treatment response, at AIDSVu.org. This set of maps and statistics focuses on PrEP use nationally and by state from 2012-2016.

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