Global Guidance

Global guidance helps set expectations, define priorities and can pave the way for national action.


For quick facts on WHO's updated PrEP recommendation, click here.

For the full report, click below.
Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection — Second edition
In June 2016, WHO released guidelines on the diagnosis of HIV infection, the use of ARVs for treating and preventing HIV infection and the care of people living with HIV. They are structured along the continuum of HIV testing, prevention, treatment and care. This edition updates the 2013 consolidated guidelines on the use of antiretroviral drugs following an extensive review of evidence and consultations in mid-2015.

Oral Pre-Exposure Prophylaxis–Putting a New Choice in Context
This 2015 publication, produced collaboratively between UNAIDS, WHO and AVAC, is intended to complement forthcoming WHO recommendations and support the optimal use of oral PrEP to protect individuals and contribute to ending the AIDS epidemic.

Recommendations on the Use of Daily oral PrEP for All Populations – PEPFAR Scientific Advisory Board (SAB)
Created in late 2015 by PEPFAR’s PrEP Expert Working Group for the PEPFAR Scientific Advisory Board, this report explores the logistics, support and priorities needed for PEPFAR-funded programs to successfully implement PrEP.

Consolidated Guidelines on HIV Prevention, Diagnosis, Treatment and Care for Key Populations
In 2014, WHO updated its Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection to include a recommendation of PrEP as a prevention option for gay men and other men who have sex with men; this document also recognizes the utility of PrEP for serodiscordant couples in some contexts.

PrEP Demonstration Projects: A Framework for Country Level Protocol Development
Issued by the World Health Organization in 2013.

Guidance on Pre-Exposure Oral Prophylaxis (PrEP) for Serodiscordant Couples, Men and Transgender Women Who Have Sex with Men at High Risk of HIV
Issued by the World Health Organization in 2012.

This page will be updated as additional global guidance and decision-maker tools are developed and disseminated by WHO and UNAIDS.

News Spotlight

  • PrEPcost.org Launches

    November 8, 2017

    This site matches individuals who are interested in PrEP to eligible health plans and provides comparative pricing. PrEPcost.org is designed for both PrEP users and health care providers to make it easy to navigate the insurance options and find the best plans available.

    Read more

  • Health Dept to Place New HIV Prevention at Uni

    September 26, 2017

    iafrica.com reports on a decision by South Africa’s Department of Health to roll out PrEP to its university system. An initiative of the Higher Education and Training HIV/AIDS Programme (HEAIDS) is making PrEP available to students for the first time. PrEP will be available in 11 clinics at seven universities. Up to now, government programs have been aimed at reaching sex workers and men who have sex with men.

    Read more