Skip to content
An Initiative of AVAC
Search
Back to Country Data

Country Overview:
Lesotho

Global PrEP Tracker
Last Updated: 19 June 2025

Drug Registration Status

Approved
Pending
Not
Approved
Lenacapavir (LEN) for PrEP — Gilead
Data Not Available
Cabotegravir (CAB) for PrEP — ViiV
Approved 2022 † 2022 †
Dapivirine Vaginal Ring (DVR) — Pop Council
Approved 2022 2022
Oral PrEP TDF/FTC — Gilead (Truvada)
Approved 2016 2016
Oral PrEP TDF/xTC* - generic
Approved
Oral PrEP F/TAF — Gilead
Data Not Available
* TDF/xTC refers to tenofovir disoproxil fumarate (TDF) and either emtricitabine (FTC) or lamivudine (3TC)

Additional Product Approvals Information for Lesotho

† This country uses an alternate pathway for regulatory approval for these products. This country relies on approval from the South African Health Products Regulatory Authority (SAHPRA) and pre-qualification from the World Health Organization (WHO) to authorize an Import License.

Research, Demonstration and Implementation

Oral PrEP

2 Completed Projects

Dapivirine Vaginal Ring

1 Planned/Ongoing Projects

Injectable PrEP

1 Planned/Ongoing Projects

Policy Frameworks

National Guidelines on the Use of Antiretroviral Therapy For HIV Prevention and Treatment (2016)

National HIV & AIDS Strategic Plan 2018/19-2022/23

Est. Cumulative
Initiations:

Total PrEP: 143,335

Oral PrEP: 143,335

Dapivirine Vaginal Ring: N/A

Injectable PrEP: N/A

Featured Resources

Document

Lesotho Strategic Direction Summary, 2023

PEPFAR Lesotho’s Country Operational Plan (COP) for 2023 – referred to as COP23 – is the culmination of work from the PEPFAR Lesotho interagency team, in collaboration with the Government of Lesotho, the Global Fund to Fight AIDS, Tuberculosis and Malaria, civil society organizations, and stakeholders. The LePHIA2020 demonstrated that Lesotho achieved the UNAIDS 90-90-90…
Document

Digital Health Landscaping Report

This landscape analysis aimed to identify common virtual channels used in several countries, estimate the number of users of each channel, and categorize countries into one of three groups based on potential for interventions to use virtual channels to succeed. Users were defined as adolescent girls and young women (aged 15–24), pregnant or breastfeeding people…
Document

Social and Behaviour Change Communication Strategy for Sexual & Reproductive Health, Rights & HIV in Lesotho 2020-21 to 2022-23

Lesotho’s Social and Behaviour Change Communication Strategy is a strategic response to the high levels of HIV and TB prevalence in the country that are exacerbated by the persistence of structural and sio-economic difficulties, such as poverty, unemployment, gender inequality and more. This strategy aims to address these issues.
Document

Final Revised National Monitoring & Evaluation Plan on HIV, 2016

In response to the 2011/12-2017/18 National Strategic Plan on HIV, this Monitoring and Evaluation Framework is designed to track and assess key HIV programs in-country, critical indicators and enablers of access to HIV programs, and respond to and report the needs of the government, development partners, implementing partners, the private sector, academia, and researchers.
External Link

Social & Behavior Change Communication Implementation Kits

These several kits aim to help service delivery project managers effectively use service communication to enhance the impact of their project. This includes helping increase demand for and uptake of services, and improving consistent long-term maintenance of healthy behaviors. It is designed to help users understand key service communication concepts, apply SBCC techniques to create…
View All Resources