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The Long-Acting Therapeutics Patents and Licenses Database (LAPaL)

3 May 2023

The Long-Acting Therapeutics Patents and Licenses Database (LAPaL) is a free online database that provides information on long-acting therapeutics that could have impact in resource-constrained settings. It includes technical and intellectual property information on these technologies as well as an interactive visualisation tool to navigate the pipeline progress.

Click here for a brief overview of the information available on LAPaL.

Topic(s): Research

Product(s): Trial Prep Options

Format(s): External Link

Source(s): Medicines Patent Pool

Type: External Link

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Featured Resources

External Link

Factors Influencing the Uptake of a Mono-PrEP Implant for the Prevention of HIV: Males’ perspectives from three South African provinces

This article from PLOS One describes the results of a study which aimed to estimate the potential uptake of a mono-PrEP implant and the factors influencing uptake among males in South Africa. The study also examined messaging and demand creation tactics that males perceive will improve HIV prevention uptake.
External Link

A Randomized Trial of Safety, Acceptability and Adherence of Three Rectal Microbicide Placebo Formulations Among Young Sexual and Gender Minorities Who Engage in Receptive Anal Intercourse (MTN-035)

This journal article from PLOS ONE was a trial seeking to evaluate the safety, acceptability, and adherence to three placebo modalities (insert, suppository, enema) prior to receptive anal intercourse (RAI).
External Link

Incorporating End-users’ Voices into the Development of an Implant for HIV Prevention: A discrete choice experiment in South Africa and Zimbabwe

This article from BMC Women’s Health describes the results of a discrete choice experiment undertaken with adolescent girls and young women in South Africa and Zimbabwe where participants were asked their preferences for a hypothetical HIV prevention implant.
External Link

Long-acting HIV Pre-exposure Prophylaxis (PrEP) Approaches: Recent advances, emerging technologies, and development challenges

This review from Expert Opinion on Drug Delivery discusses the current state of the long acting PrEP field, recent advances, and emerging technologies, including ARV prodrug modifications and new drug delivery systems. Technological challenges, knowledge gaps, preclinical testing considerations, and future directions important in the context of clinical translation and implementation of long acting HIV…
External Link

End-user Research in Support of Long-acting Systemic Antiretroviral Delivery Systems: Insights from qualitative research with providers and target users in South Africa

This article from BMC Infectious Diseases describes qualitative research investigating perceptions of and preferences for a long-acting, biodegradable implantable PrEP product designed to address challenges relating to adhering to a daily pill regimen amongst adolescent girls and young women and sex workers in Guateng Province, South Africa.
External Link

A Randomized, Double-Blind, Placebo-Controlled, Phase 1 Trial of Radiopaque Islatravir-Eluting Subdermal Implants for Pre-exposure Prophylaxis Against HIV-1 Infection

This article from JAIDS describes the results of a randomized, double-blind, placebo-controlled, phase 1 trial of a next-generation radiopaque islatravir-eluting implant to assess safety, tolerability, and pharmacokinetics.
External Link

More than Just Oral PrEP: Exploring interest in rectal douche, dissolvable implant, removable implant and injection HIV prevention approaches among racially diverse men who have sex with men in the Northeast Corridor

This exploratory and cross-sectional study investigated interest in four biomedical prevention tools—rectal douche, dissolvable implant, removable implant and injection—among a racially diverse sample of men who have sex with men from the Northeast Corridor region between Philadelphia and Trenton.
External Link

HIV Prevention Research and Development Database

The HIV Prevention Research & Development Database is a comprehensive source of information on biomedical HIV prevention clinical trials that are planned, ongoing or completed. The database allows users to view clinical trials around the world, gaining an understanding of the many developments currently being made in the field of HIV prevention research.
External Link

The Years Ahead in Biomedical HIV Prevention Research

This graphic shows the updated status of large-scale prevention trials through 2024.
External Link

The Future of ARV-Based Prevention and More

The pipeline of non-vaccine HIV prevention products includes oral pills, vaginal rings, vaginal and rectal gels, vaginal films, long-acting injectable antiretrovirals and more. Also pictured are the range of multipurpose prevention technologies in development that aim to reduce the risk of HIV and STIs and/or provide effective contraception for women.