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Country Overview:
South Africa

Global PrEP Tracker
Last Updated: 28 November 2023

Drug Registration Status

Approved
Not
Approved
Under
Review
Data not
available
Gilead's Truvada (TDF/xTC*) Registration
Approved 2015 2015
Generic versions of TDF/xTC* for prevention
Approved N/A N/A
ViiV's Apretude (CAB for PrEP) Registration
Approved 2022 2022
IPM's Dapivirine Vaginal Ring Registration
Approved 2022 2022
Oral F/TAF (Descovy) Registration
Not Approved
* TDF/xTC refers to tenofovir disoproxil fumarate (TDF) and either emtricitabine (FTC) or lamivudine (3TC)

Research, Demonstration and Implementation

Oral PrEP

34 Completed Projects

Dapivirine Vaginal Ring

4 Planned/Ongoing Projects

Injectable PrEP

9 Planned/Ongoing Projects

Policy Frameworks

South African Guidelines for the Provision of Pre-exposure Prophylaxis (PrEP) to Persons at Substantial Risk of HIV Infection, 2020

National Strategic Plan for HIV, TB and STIs, 2017-2022

National Sex Worker HIV Plan, 2016-2019

National Policy on HIV PrEP and Test and Treat, 2016

Est. Cumulative
Initiations:

Total PrEP: 1,175,420

Oral PrEP: 1,175,293

Dapivirine Vaginal Ring: 127

Injectable PrEP: N/A

PEPFAR Targets in
COP 2023:

Total PrEP: 250,364

Oral PrEP: 250,364

Dapivirine Vaginal Ring: N/A

Injectable PrEP: N/A

Where To Access PrEP in South Africa:

Get PrEP

HIV Care Now

Featured Resources

Document

South Africa PrEP Implementation Study Mapping Analysis

This analysis aims to investigate which questions will/will not be addressed by the current slate of ongoing or planned implementation science to inform decisions about investments in additional research (if needed) and provide an understanding of when insights across key questions will become available to help inform the rollout planning for the new PrEP methods…
Document

South Africa COP, 2022

The goal of South Africa’s 2022 Country Operational Plan is to maintain progress from 2021 in key areas related to health promotion such as refining efforts to eliminate policy barriers, insitutionalizing client- centered services, helping the country achieve 95-95-95, and spotlighting HIV prevention and treatment access for all populations in need.
Document

Stakeholder Conversations to Inform Delivery of New HIV Prevention Methods in South Africa

A readout of conversations with local stakeholders about the dapivirine vaginal ring, looking to gain insight on implementation considerations from providers and potential end-users.
Presentation

Breaking the Cycle of HIV Transmission: A Human Centered Design Approach to Reach Adolescent Girls and Young Women

Many Adolescent Girls and Young Women (AGYW) at high risk for HIV have difficulties sustaining prevention behaviors. To address this challenge, Upstream and Final Mile used Human Centered Design (HCD) methodologies to undertake behavioral research and design and pilot an intervention. Over 3,000 AGYW and 135 influencers (such as male partners and community health workers)…
Document

Dapivirine Ring Early Introduction Considerations — South Africa Analysis

The OPTIONS Consortium conducted secondary research and interviews with key stakeholders in several countries to understand questions about the ring that could inform demonstration and processes for introducing new biomedical HIV prevention products. South Africa was prioritized for analysis due to the state of the HIV epidemic in the country and experience with ring trials.…
Document

Monitoring & Evaluation Plan for the National Strategic Plan on HIV, TB, & STIs, 2017-22

South Africa’s M&E Plan builds on achievements in the fight against HIV/AIDS from the past and continues to lay the groundwork for collecting vital information for this effort into the future. It informs how to improve and scale up service delivery and implementing evidence-based interventions. This Plan also outlines the key indicators, their definitions, data…
Document

Oral PrEP Youth Dialogues South Africa

The OPTIONS Consortium, in close collaboration with the South African Department of Health, developed the creative concept ‘We Are The Generation That Will End HIV’ and applied it to all information, education and communication (IEC) material. The creative concept aimed to generate demand for oral PrEP as an additional and acceptable HIV prevention method. Short…
View All Resources