A snapshot of PrEP scale-up, registration and resources for Lesotho.

  • 63,000-64,000
    Estimated Cumulative Number of People Initiating PrEP

    Aggregates numbers reported from demonstration projects, PEPFAR dashboard and program/country reports where available. This is presented as a range due to difficulty in tracking precise numbers and possible double reporting.

  • 24,632
    PEPFAR PrEP Target in COP 2022

    Targets are set by PEPFAR country teams on an annual basis. Targets do not indicate funding is available for PrEP.

Data Updated: May 16, 2022

Drug Registration Status

  • Gilead's Truvada (TDF/FTC) registration
  • Generic versions of TDF/FTC for prevention
  • Viiv’s Apretude (CAB for PrEP) Registration
    Not approved
  • IPM’s Dapivirine Ring Registration

Types of Projects

  • Large-scale implementation initiative — funded/implementer involvement and investment in some or all steps related to comprehensive introduction that may or may not use government clinics as the primary service delivery point – e.g., Kenya’s Jilinde program.

Policy Framework


  • The Bill & Melinda Gates Foundation
  • Nike Foundation

Eligibility Criteria

Oral PrEP is recommended for HIV-negative individuals at ‘significant risk’ of becoming infected with HIV. ‘Significant risk’ is defined as a three percent risk of being infected with HIV in one year. An individualized risk assessment should be performed for HIV-negative individuals in order to determine if PrEP is an appropriate HIV prevention strategy. The risk assessment should inquire about known high risk behaviors for acquiring HIV. Although it is important to conduct a risk assessment for each HIV-negative person before offering PrEP, the following groups of people are suggested for targeting of PrEP services based on high risk behaviors:

  • Exchanged sex for money
  • Paid for sex
  • Men who have sex with men and transgender people
  • People who inject drugs
  • In serodiscordant relationship and HIV-positive partner is not on ART
  • In serodiscordant relationship and HIV-positive partner has been on ART for < 12 months
  • In serodiscordant relationship and HIV-positive partner’s viral load is 1000 copies/ml or recent viral load is not known but partner’s ART adherence is documented to be poor
  • Multiple concurrent sexual partners
  • Incarcerated individuals

Resources for Lesotho

Lesotho Demand Creation Materials