An Initiative of AVAC

South Africa

A snapshot of PrEP scale-up, registration and resources for South Africa.

  • 16,000-17,000
    Estimated Number of Current PrEP Users

    Aggregates numbers reported from demonstration projects, PEPFAR dashboard and program/country reports where available. This is presented as a range due to difficulty in tracking precise numbers and possible double reporting.

  • 2,000
    National Health System Targets

    National targets put forward by governments may be aspirational and/or indicative of estimated need; or they may be low or nonexistent if PrEP is solely available via demonstration projects. In some instances, national targets may not include targets from all planned and ongoing PrEP demonstration projects. For these reasons, a calculation of current PrEP users as a percentage of this target will not necessarily reflect accurate progress in PrEP initiations at the country level.

  • 18,826
    PEPFAR PrEP Target in COP 2018

    Targets are set by PEPFAR country teams on an annual basis. Targets do not indicate funding is available for PrEP.

Data Updated: December 31, 2018

Drug Registration Status

  • Gilead's Truvada (TDF/FTC) registration
    Approved
  • Generic versions of TDF/FTC for prevention
    Approved

Types of Delivery Projects

  • Behavioral and social science projects
  • Clinical trials
  • Demonstration projects — which road-test the use of new options in real-world settings—not in a trial site. They have a formal evaluation component that is designed to address specific elements of introduction such as infrastructure needs and ways individuals can integrate it into daily activities.
  • Implementation projects
  • Large-scale implementation initiative — funded/implementer involvement and investment in some or all steps related to comprehensive introduction that may or may not use government clinics as the primary service delivery point – e.g., Kenya’s Jilinde program.
  • Open-label extension
  • Product introduction and support projects

Research, Demonstration and Implementation Projects

Policy Framework

Funding

  • NIAID
  • NIMH
  • NICHD
  • USAID
  • The Bill & Melinda Gates Foundation
  • PEPFAR
  • NIH
  • UNITAID
  • Anova Health Institute
  • Desmond Tutu HIV Foundation
  • Elton John AIDS Foundation
  • CAPRISA
  • DAIDS
  • IMPAACT Network
  • MSF
  • MTN
  • IPM
  • Nike Foundation
  • Wits RHI
  • London School of Hygiene & Tropical Medicine

Selected Technical & Strategic Assistance

Eligibility Criteria

PrEP should be considered for people who are HIV-negative and at significant risk of acquiring HIV infection. PrEP may be suitable for:

Any sexually active HIV-negative MSM or transgender person who wants PrEP

  • those with HIV-positive sexual partner(s) who are not confirmed virologically suppressed
  • partner(s) of unknown HIV status
  • recent STI
  • multiple sexual partners
  • history of inconsistent or no condom use
  • commercial sex work
  • recurrent PEP users
  • history of sex whilst under the influence of alcohol or recreational drugs

Heterosexual women and men who want PrEP, targeting especially

  • those with HIV-positive sexual partner(s) who are not confirmed virologically suppressed
  • partner(s) of unknown HIV status
  • recent STI
  • multiple sexual partners
  • history of inconsistent or no condom use
  • commercial sex work
  • serodiscordant couples trying to conceive
  • recurrent PEP users
  • history of sex whilst under the influence of alcohol or recreational drugs

people who inject drugs

  • HIV-negative PWID with HIV-positive/unknown status injecting partner(s)
  • share injecting needles and drug preparation equipment

All of the above groups include adolescents and sex workers, which each constitute special groups meriting specific consideration

  • especially vulnerable are young MSM and adolescent girls

Resources for South Africa

South Africa Job Aids

These South Africa-specific job aids were created to support health care workers, peer educators, and counselors at oral PrEP rollout sites. The adherence counseling guide and checklist aim to assist counselors and health care workers with discussing oral PrEP initiation and adherence. “The Road to PrEP” poster details, in visual format, the steps required to refer HIV-positive clients for immediate test and treat, as well as the counseling and oral PrEP initiation for HIV-negative clients. Finally, the palm card educates the potential user about oral PrEP.

For South Africa specific information, education and communication materials, visit this page.