Resource Library

South Africa Lenacapavir Implementation Guidelines, 2025

This guideline, developed by South Africa’s National Department of Health, is intended to provide comprehensive clinical, programmatic, and operational direction for the safe, effective, and equitable rollout of lenacapavir as a long-acting injectable option for HIV PrEP in South Africa.

Normative Guidance/Policies

BLUPrInt PrEP Program Builder

The BLUPrInt PrEP Program Builder breaks down the process of making PrEP – whether oral or injectable – available in your setting into six manageable and coherent program components. Each program component includes a Step-by-Step Guide that presents key decision points and health equity considerations that are crucial to PrEP program development, a templated Standard…

Demand Creation/Marketing, Service Delivery, Supply Chain Management

Site/Facility Readiness Assessment Tool to Support Lenacapavir for HIV Prevention Introduction

This tool, developed by Wits RHI and CHAI with support from Unitaid, is intended to provide insight into the current state of PrEP services and to identify critical barriers and facilitators to PrEP implementation with a focus on preparing for Lenacapavir (LEN) introduction according to national requirements. Findings from readiness assessment visits using this tool…

Service Delivery

Innovative HIV Prevention and Treatment Keynote and Panel Discussion

Can a Twice-Yearly PrEP Injection Curb the HIV Pandemic? Join the O’Neill Institute for an in-depth discussion on Lenacapavir, a groundbreaking long-acting injectable PrEP formulation administered just twice a year. This session will examine its potential to transform HIV prevention on a global scale, looking at the latest clinical evidence, regulatory pathways, and the access…

Lenacapavir Provider Tools and Job Aids

These editable tools, developed by Wits RHI, can be used to support providers delivering lenacapavir (LEN) for PrEP. The downloadable zip file includes: LEN Factsheet for Clients LEN Counselling Job Aid for Clinicians LEN Counselling Job Aid for Counsellors LEN Initiation Algorithm LEN Injection Procedure Chart HIV Prevention Product Comparison Table LEN Stopping and Switching…

Service Delivery

The New Frontier in HIV Pre-exposure Prophylaxis: Lenacapavir Update

In the ongoing search for new methods to address the HIV epidemic, the development of lenacapavir for HIV prevention is a major step forward. Findings from research studies has shown that twice-yearly injection of long-acting lenacapavir provides protection against HIV infection. This discovery offers great promise in advancing our progress towards ending AIDS as a…

Research

Prevention with PURPOSE

This presentation, delivered by Dr Linda-Gail Bekker at IAS 2025, provides an overview of PURPOSE 1 and 2 lenacapavir clinical trial results as well as special considerations for administration to different populations and drug-drug interactions.

Research

What Can Modelling Tell Us about the Scale-up of Lenacapavir for Pre-exposure Prophylaxis?

This brief provides a synthesis of evidence from mathematical modelling, as of June 2025, arising from a meeting of programme managers, civil society representatives, mathematical modellers and international HIV prevention stakeholders convened by the Gates Foundation and the Joint United Nations Programme on HIV/AIDS (UNAIDS). The meeting focused on questions currently being considered by HIV…

Research

Empowering Women’s PrEP Choices: Qualitative Insights into Long-Acting PrEP Preferences and Decision-Making during Pregnancy and Breastfeeding in South Africa and Botswana

This article from AIDS and Behavior explores preferences for various long-acting PrEP modalities amongst pregnant and lactating people in Botswana and South Africa. It further examines participants’ HIV risk perception during pregnancy and breastfeeding, their perceived individual-level facilitators and barriers of each PrEP modality, and the support needed by participants for PrEP uptake and continuation.

Research, Service Delivery

From Oral PrEP to LEN: Leveling Up Prevention with the WHO–Jhpiego PrEP Provider Training Toolkit

Recording / Slides This 90-minute webinar, presented by Jhpiego and WHO, is intended for communities, providers, policy makers and advocates interested in pre-exposure prophylaxis (PrEP) for HIV prevention. The presenters will provide an overview of the recently launched WHO and Jhpiego Provider Training Toolkit on Use of Oral and Long-Acting HIV PrEP with case-based scenarios…

Service Delivery