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Resource Library

The PrEPWatch Resource Database offers a wide range of material on the status of PrEP as an option for biomedical HIV prevention around the world. Search this database to find step-by-step guidance for rolling out PrEP, summaries of the research to date on safety, efficacy and implementation, tools to assist planning and roll out, country updates on PrEP policy and access, and lessons learned from those efforts.

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30 September 2025

Dynamic Choice HIV Prevention with Long-acting Injectable Cabotegravir Pre-exposure Prophylaxis in East, Central, Southern, and West Africa: A cost-effectiveness modelling analysis

In randomised controlled trials in Kenya and Uganda, a dynamic choice HIV prevention intervention that offered structured choice of biomedical prevention product and opportunity to change products over time substantially improved prevention coverage; incident HIV infections were eliminated when long-acting cabotegravir was included as an option. This article from The Lancet HIV aims to assess…

Financing & Costing, Research, Service Delivery

External Link
25 September 2025

Empowering Women’s PrEP Choices: Qualitative Insights into Long-Acting PrEP Preferences and Decision-Making during Pregnancy and Breastfeeding in South Africa and Botswana

This article from AIDS and Behavior explores preferences for various long-acting PrEP modalities amongst pregnant and lactating people in Botswana and South Africa. It further examines participants’ HIV risk perception during pregnancy and breastfeeding, their perceived individual-level facilitators and barriers of each PrEP modality, and the support needed by participants for PrEP uptake and continuation.

Research, Service Delivery

External Link
25 September 2025

HIV Country Planning Hub

This platform, hosted by GBGMC in partnership with national civil society groups and technical collaborators, features national HIV prevention and treatment plans developed by and for communities most critical to reaching the last mile of the HIV response. Each plan reflects local priorities and community-led strategies to reach populations most affected by HIV.

Community/Advocacy, Normative Guidance/Policies

External Link
1 September 2025

“…this could be a noble idea and a game changer.” The Potential of a Dual Prevention Pill for HIV and Pregnancy Prevention among Adolescent Girls and Young Women in Zimbabwe

This article from PLOS Global Public Health describes the opinions of adolescent girls and young women and health care providers in Zimbabwe regarding the dual prevention pill (DPP), combining oral contraceptives with oral PrEP to simultaneously prevent unintended pregnancy and HIV.

Research

External Link
24 July 2025

Southern African HIV Clinicians Society Guideline on Pre-Exposure Prophylaxis to Prevent HIV (2025)

This guideline is an update to the Southern African HIV Clinicians Society (SAHCS) 2020 recommendations on HIV PrEP. Previous SAHCS guidance was limited to the provision of oral emtricitabine/tenofovir disoproxil fumarate (F/TDF) PrEP. This update includes newer PrEP modalities, including the monthly dapivirine vaginal ring (DVR) and the long-acting cabotegravir intramuscular injection (CAB-LA). It also…

Normative Guidance/Policies

External Link
24 July 2025

South African Guidelines for the Provision of Pre-exposure Prophylaxis (PrEP) to Persons at Substantial Risk of HIV Infection- 2021 Update

These PrEP guidelines, developed by the South African National Department of Health and released in 2021, serve as an update to the 2020 national PrEP guidelines.

Normative Guidance/Policies

Document
18 July 2025

PEP in Africa: Prospects, opportunities, and challenges

This special JIAS supplement illustrates current PEP advances and challenges to improve the delivery and uptake of PEP across sub-Saharan Africa.

Research, Service Delivery

External Link
16 May 2025

The Impact of the PEPFAR Funding Freeze on HIV Deaths and Infections: A mathematical modelling study of seven countries in sub-Saharan Africa

This article from eClinicalMedicine estimates the impact of PEPFAR stop work orders on new HIV infections in Ethiopia, Kenya, Malawi, South Africa, Tanzania, Zambia, and Zimbabwe.

Research, Service Delivery

External Link
9 April 2025

A Mixed-Method Study of Feasibility and Acceptability of the Dapivirine Vaginal Ring among Adolescent Girls and Young Women (AGYW) in Selected Zimbabwean Districts

This article from PLOS Global Public Health describes the results of a study assessing the acceptability and feasibility of introducing the dapivirine vaginal ring (DVR) as an HIV prevention method among young women in Zimbabwe and to assess motivations and barriers of DVR uptake among the target population.

Research, Service Delivery

External Link
8 April 2025

Guidance for Developing a National Male Engagement Strategy for HIV Prevention

This guidance, produced by the South-to-South Learning Network, can help decision-makers at national level, sub-national level, and at programme level to develop a national male engagement strategy for HIV prevention. This guidance is focussed on vulnerable men who are not a member of a key population.

Community/Advocacy, Demand Creation/Marketing, Service Delivery

Document