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BLUPrInt PrEP Program Builder

14 November 2025

The BLUPrInt PrEP Program Builder breaks down the process of making PrEP – whether oral or injectable – available in your setting into six manageable and coherent program components. Each program component includes a Step-by-Step Guide that presents key decision points and health equity considerations that are crucial to PrEP program development, a templated Standard Operating Procedures that you can customize to your setting, and one or more job aids to support staff in standardizing work.

Topic(s): Demand Creation/Marketing, Service Delivery, Supply Chain Management

Product(s): Cabotegravir, Injectable Prep, Lenacapavir, Oral PrEP

Format(s): Toolkit

Source(s): BLUPrInt

Type: External Link

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Featured Resources

Spreadsheet

Site/Facility Readiness Assessment Tool to Support Lenacapavir for HIV Prevention Introduction

This tool, developed by Wits RHI and CHAI with support from Unitaid, is intended to provide insight into the current state of PrEP services and to identify critical barriers and facilitators to PrEP implementation with a focus on preparing for Lenacapavir (LEN) introduction according to national requirements. Findings from readiness assessment visits using this tool…
Document

Getting LEN Rollout Right: Resources and Tools

The resources listed in this document, alongside insights drawn from the report Getting PrEP Rollout Right This Time, can support countries in the early stages of LEN planning. These tools are being disseminated as part of a coordinated effort between AVAC, CHAI, the Global Fund, PEPFAR, Unitaid, Wits RHI, and WHO under the Coalition to…
Document

Consolidated Guidelines for the Prevention and Treatment of HIV and AIDS in Uganda, 2022

These guidelines, produced in 2022 by the Uganda Ministry of Health, provide guidance on the diagnosis of HIV, the care of people living with HIV, and the use of antiretroviral drugs for treating and preventing HIV infection, including injectable cabotegravir and the dapivirine vaginal ring.
Document

Malawi Service Delivery Guidelines and Standard Operating Procedures for the Provision of HIV Pre-Exposure Prophylaxis using Oral or Long-acting Injectable Options (2024)

The document, produced by the Malawi Ministry of Health, is a guideline to support funders, implementing partners, district health team leads and service providers in implementing Oral and Long-Acting Injectable PrEP in Malawi.
External Link

Preferences for Long-acting Injectable HIV Pre-exposure Prophylaxis Service Delivery among Male and Female Sex Workers in Uganda: A discrete choice experiment

This article from PLOS Global Public Health explores service delivery preferences for injectable cabotegravir among heterosexual male sex workers and female sex workers in Uganda.
Document

Lenacapavir Provider Tools and Job Aids

These editable tools, developed by Wits RHI, can be used to support providers delivering lenacapavir (LEN) for PrEP. The downloadable zip file includes: LEN Factsheet for Clients LEN Counselling Job Aid for Clinicians LEN Counselling Job Aid for Counsellors LEN Initiation Algorithm LEN Injection Procedure Chart HIV Prevention Product Comparison Table LEN Stopping and Switching…
Presentation

Prevention with PURPOSE

This presentation, delivered by Dr Linda-Gail Bekker at IAS 2025, provides an overview of PURPOSE 1 and 2 lenacapavir clinical trial results as well as special considerations for administration to different populations and drug-drug interactions.
External Link

Dynamic Choice HIV Prevention with Long-acting Injectable Cabotegravir Pre-exposure Prophylaxis in East, Central, Southern, and West Africa: A cost-effectiveness modelling analysis

In randomised controlled trials in Kenya and Uganda, a dynamic choice HIV prevention intervention that offered structured choice of biomedical prevention product and opportunity to change products over time substantially improved prevention coverage; incident HIV infections were eliminated when long-acting cabotegravir was included as an option. This article from The Lancet HIV aims to assess…
External Link

What Can Modelling Tell Us about the Scale-up of Lenacapavir for Pre-exposure Prophylaxis?

This brief provides a synthesis of evidence from mathematical modelling, as of June 2025, arising from a meeting of programme managers, civil society representatives, mathematical modellers and international HIV prevention stakeholders convened by the Gates Foundation and the Joint United Nations Programme on HIV/AIDS (UNAIDS). The meeting focused on questions currently being considered by HIV…
External Link

Empowering Women’s PrEP Choices: Qualitative Insights into Long-Acting PrEP Preferences and Decision-Making during Pregnancy and Breastfeeding in South Africa and Botswana

This article from AIDS and Behavior explores preferences for various long-acting PrEP modalities amongst pregnant and lactating people in Botswana and South Africa. It further examines participants’ HIV risk perception during pregnancy and breastfeeding, their perceived individual-level facilitators and barriers of each PrEP modality, and the support needed by participants for PrEP uptake and continuation.