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South Africa’s M&E Plan builds on achievements in the fight against HIV/AIDS from the past and continues to lay the groundwork for collecting vital information for this effort into the future. It informs how to improve and scale up service delivery and implementing evidence-based interventions. This Plan also outlines the key indicators, their definitions, data sources, data collection tools, data flow mechanisms, reporting timelines, and the roles and responsiblities of all key stakeholders.