Elimination of vertical transmission of HIV will require expanded access to HIV prevention strategies, such as PrEP, for pregnant and breastfeeding people.
Guidance from the World Health Organization (WHO) supports provision of HIV pre-exposure prophylaxis (PrEP) to pregnant and breastfeeding people (PBFP) who are at continuing substantial risk of HIV infection. Evidence has shown that people have an increased need for HIV prevention during pregnancy and the postnatal period, and that people who become infected with HIV during pregnancy or the postnatal period have a higher chance of transmitting HIV to their infants as compared to people who became infected with HIV before becoming pregnant.
To better understand the extent to which PrEP has been included in national prevention strategies for vertical transmission in MOSAIC countries, MOSAIC reviewed the current status of PrEP inclusion for PBFP in national vertical transmission policies, including prevention of mother to child transmission (PMTCT) or elimination of mother to child transmission (eMTCT) policies, across eight MOSAIC-supported countries (Eswatini, Kenya, Lesotho, Namibia, South Africa, Uganda, Zambia, and Zimbabwe). Findings from this review are summarized in the brief titled “Rapid Landscape Analysis of National Vertical Transmission Policies for Inclusion of HIV Pre-exposure Prophylaxis for Pregnant and Breastfeeding People.”
The Lancet HIV- Special Issue on PrEP
The December 2023 issue of The Lancet HIV contains numerous articles featuring the latest research and commentaries on PrEP, including oral PrEP, injectable CAB for PrEP, the dapirivine vaginal ring, and PEP.
What can modelling tell us about the scale-up of CAB for PrEP?
This factsheet summarises the results of mathematical modelling exercises of Cabotegravir (CAB) for PrEP rollout undertaken by researchers affiliated with the HIV Modelling Consortium. These results can help implementers and policymakers understand what to expect and guide early policy decisions to ensure CAB for PrEP is able to have maximum impact on reducing the HIV…
Daily Oral PrEP, Event-Driven PrEP, PrEP Ring, and CAB PrEP Template Guidelines (English)
The intent of this document is to provide adaptable guidelines to support the development and adoption of national guidelines that align with World Health Organization (WHO) pre-exposure prophylaxis (PrEP) recommendations and guidance, including those for tenofovir disoproxil fumarate (TDF)-based daily and event-driven oral PrEP, the monthly dapivirine vaginal ring (“PrEP ring” or “the ring”), and…
Quality Improvement Brief
The Quality Improvement Collaborative (QIC) is a component of the CATALYST study that refines and makes context-specific improvements to the enhanced service delivery package to make it scalable for delivering PrEP choice. The QIC’s multi-country design enables rich learning and problem-solving by providing QI faculty, advisors, coaches, and teams from all CATALYST countries opportunities to…
Insights Report: Communicating the PrEP Category to AGYW
PrEP Category Positioning Market Research Validation Insights from Kenya, South Africa, and Zimbabwe This report is a comprehensive look at what was learned through validating the positioning direction. It explains the methodology, outlines country-specific reactions to the positioning direction, and distills key findings that were leveraged to adjust and refine the positioning to honor the…
Communicating the PrEP Category to Adolescent Girls and Young Women
This strategy brief is intended for use by implementers working to generate demand for PrEP among AGYW. Drawing on all learnings throughout the positioning process, the brief provides a narrative explanation of how to communicate the PrEP category to AGYW and includes actionable guidance on how best to develop communication that will get the attention…
PrEP Product Awareness, Preferences, and Past Experiences among Transgender Women and Men Who Have Sex with Men in Asia and Australia: The PrEP APPEAL Study
This report provides an overview of PrEP Product Awareness, Preferences, and Past Experiences among Transgender Women and Men Who Have Sex with Men in Asia and Australia (PrEP APPEAL), a survey study in 16 countries and territories in Asia and Australia. The overall goal of PrEP APPEAL was to identify values and preferences about PrEP,…
Efficacy and Safety of Long-Acting Cabotegravir Compared with Daily Oral Tenofovir Disoproxil Fumarate Plus Emtricitabine to Prevent HIV Infection in Cisgender Men and Transgender Women who Have Sex with Men 1 Year after Study Unblinding: A secondary analysis of the phase 2b and 3 HPTN 083 randomised controlled trial
This article from The Lancet HIV describes findings from the first unblinded year of the HIV Prevention Trials Network (HPTN) 083 study, which compared safety and efficacy of cabotegravir and tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) as HIV prevention for transgender women and men who have sex with men in Argentina, Brazil, Peru, South Africa, Thailand, the…
How Might We Motivate Uptake of the Dual Prevention Pill? Findings from human-centered design research with potential end users, male partners, and healthcare providers
This article from Frontiers in Reproductive Health describes the results of a study to identify barriers and motivators for Dual Prevention Pill (DPP) uptake to inform the development of a DPP demand generation strategy and broader introduction efforts for Multipurpose Prevention Technologies.
Adherence, Safety, and Choice of the Monthly Dapivirine Vaginal Ring or Oral Emtricitabine Plus Tenofovir Disoproxil Fumarate for HIV Pre-exposure Prophylaxis among African Adolescent Girls and Young Women: A randomised, open-label, crossover trial
This article from the Lancet HIV assesses product adherence, safety, and choice of oral PrEP compared with the dapivirine ring among adolescent girls and young women in South Africa, Uganda, and Zimbabwe.