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PEP in Africa: Prospects, opportunities, and challenges

18 July 2025

This special JIAS supplement illustrates current PEP advances and challenges to improve the delivery and uptake of PEP across sub-Saharan Africa.

Topic(s): Research, Service Delivery

Product(s): Post Exposure Prophylaxis

Region(s): Sub-Saharan Africa

Format(s): Journal Article

Source(s): JIAS

Type: External Link

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Featured Resources

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PrEP Booklet of Frequently Asked Questions (FAQs): A Peer Outreach Worker Tool

This tool was developed to be used by peer outreach workers, peer educators, and other community-based health providers to help provide comprehensive information about pre-exposure prophylaxis (PrEP) to key population peers.
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PEP Template Guidelines (English)

The intent of this document is to provide adaptable guidelines to support the development and adoption of national guidelines that align with World Health Organization (WHO) post-exposure prophylaxis (PEP) recommendations and guidance. The document includes prompts for national-level consideration during the guideline adaptation process.
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HIV Prevention User Journey Tool

The HIV Prevention Journey Tool was developed to support adolescent girls and young women to explore methods that would align with their lifestyle, needs and personal preferences; and support healthcare providers to provide informed counseling based on client needs. The digital tool, which has been optimized for use on mobile devices, can be accessed here.…
External Link

Dynamic Choice HIV Prevention with Cabotegravir Long-acting Injectable in Rural Uganda and Kenya: A randomised trial extension

This article from The Lancet HIV discusses the results of the SEARCH dynamic choice study conducted in Kenya and Uganda, comparing outcomes between one group offered a choice between oral PrEP, post-exposure prophylaxis, and cabotegravir for PrEP, and a second group receiving the standard of care.
External Link

Role of HIV Self-testing in Strengthening HIV Prevention Services

This article from The Lancet HIV examines the potential role of HIV self-testing (HIVST) in achieving HIV prevention goals by looking at trials of use of HIVST with prevention tools such as pre-exposure prophylaxis (PrEP), post-exposure prophylaxis (PEP), and voluntary medical male circumcision (VMMC).
External Link

Client Experiences with “Dynamic Choice Prevention,” a Model for Flexible Patient-centred HIV Prevention Delivery in Rural Eastern Africa

This article from Journal of the International AIDS Society discusses client experiences of a dynamic choice model for HIV prevention piloted in Kenya and Uganda under the SEARCH study, where clients were supported to select HIV prevention method, testing mode, and service delivery channel from a range of options.
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Online Pharmacy PrEP and PEP: Technical considerations and learnings from Kenya

This document, developed by PATH, is intended as a how-to implementation guide for providing oral pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP) via online pharmacy service delivery (ePrEP/ePEP) based on learnings and evidence from the ePrEP Kenya pilot study that ran from October 2022 through July 2024. The guide was developed to support ministries of…
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WHO Guidelines for HIV Post-exposure Prophylaxis

These guidelines developed by the World Health Organisation outline the latest recommendations and evidence on use of post-exposure prophylaxis (PEP).
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PEP FactSheet

This tool developed by the South Africa National Department of Health is intended to support clinical education efforts related to HIV PEP.
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PEP Counseling Job Aid

This tool developed by the South Africa National Department of Health is intended to support health care providers in counseling their clients about PEP.