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With the release of the WHO Guidelines on Long-Acting Injectable Cabotegravir for HIV Prevention in 2022, HIV prevention programs and implementing partners are working to prepare for rapid expansion of additional methods of HIV pre-exposure prophylaxis (PrEP). Experience from the scale-up of previous HIV prevention programs demonstrates the advantages of ready-made provider capacity building resources that address clinical knowledge as well as key counseling messages and skills, developed specifically to align with WHO guidance and recommendations.

With funding from PEPFAR through USAID, the Reaching Impact, Saturation, and Epidemic Control (RISE) project developed a new provider training resource on use of long-acting cabotegravir (CAB for PrEP) for HIV prevention. The “Provider Training Toolkit on use of CAB for PrEP” (available at is designed to help clinicians learn about and support provision of CAB for PrEP as an HIV prevention option for their clients.

The toolkit includes a series of eLearning lessons to build provider knowledge of CAB for PrEP covering clinical information and eligibility, administration, ongoing clinical management, and counseling, including an animated demonstration of the injection technique. The eLearning lessons include job aids, algorithms, and other provider support tools that can be downloaded or printed. There are separate complementary resources to guide programs and implementing partners wishing to combine online and in-person practice through a blended learning approach, including a facilitation guide and case-based scenarios. For those limited to classroom-based training approaches, there is also a comprehensive slide deck for in-person only trainings.

CAB for PrEP Clinical and Counseling Content

Clinical Information and Eligibility

  • Lesson 1: The Basics of Cabotegravir (CAB) for HIV Prevention
  • Lesson 2: Relative Advantages and Disadvantages of Long-acting Injectable Cabotegravir (CAB for PrEP)
  • Lesson 3: CAB for PrEP Eligibility Screening

CAB for PrEP Administration

  • Lesson 4: CAB for PrEP Injection Technique (with demonstration video)

Scheduling and Follow-up Management

  • Lesson 5: Assessing and Managing Side Effects and Adverse Reactions of CAB-LA
  • Lesson 6: Follow-up Schedule and Visit Components
  • Lesson 7: Managing Missed Visits
  • Lesson 8: Using Oral PrEP as a Bridge to Postpone Reinjection Appointments
  • Lesson 9: Discontinuation of CAB-LA and Tail Phase Monitoring

Counseling Resources

  • Lesson 10: Method Choice: Framing Method Benefits Relative to Client Priorities
  • Lesson 11: Cross-Cutting Counseling Techniques
  • Lesson 12: Translating Technical Information into Counseling Messages

Pregnancy and Breastfeeding

  • Lesson 13: Special Pregnancy and Breastfeeding Considerations for CAB for PrEP

Training Resources and Approaches

  1. Digital eLearning lessons focused on building knowledge of CAB for PrEP and introducing tools for counseling, clinical assessment, and ongoing clinical management.
  2. Facilitation resources for in-person blended learning workshops for practice and application of knowledge and tools.
  3. Classroom-based training resources for use in settings where online access to the digital eLearning lessons is limited, or where classroom-based learning is preferred.

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