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Country Overview:
Zambia

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Global PrEP Tracker
Last Updated: 19 June 2025

Drug Registration Status

Approved
Pending
Not
Approved
Lenacapavir (LEN) for PrEP — Gilead
Data Not Available
Cabotegravir (CAB) for PrEP — ViiV
Approved 2023 2023
Dapivirine Vaginal Ring (DVR) — Pop Council
Approved 2021 2021
Oral PrEP TDF/FTC — Gilead (Truvada)
Approved 2017 2017
Oral PrEP TDF/xTC* - generic
Approved
Oral PrEP F/TAF — Gilead
Not Approved
* TDF/xTC refers to tenofovir disoproxil fumarate (TDF) and either emtricitabine (FTC) or lamivudine (3TC)

Research, Demonstration and Implementation

Oral PrEP

2 Completed Projects

Dapivirine Vaginal Ring

N/A Planned/Ongoing Projects

Injectable PrEP

2 Planned/Ongoing Projects

Policy Frameworks

HIV Pre & Post-Exposure Prophylaxis Guidelines in Zambia, December 2023

Implementation Plan for Introduction of Long-acting Injectable Cabotegravir for HIV Prevention, November 2023

National HIV/AIDS Strategic Framework, 2017-2021

Est. Cumulative
Initiations:

Total PrEP: 895,685

Oral PrEP: 892,572

Dapivirine Vaginal Ring: N/A

Injectable PrEP: 3,013

Where To Access PrEP in Zambia:

HIV Care Now

Featured Resources

Presentation

Overview of the 2023 Zambia Consolidated Guidelines for Treatment and Prevention of HIV

This deck provides an overview of the evidence based recommendations, cost-effectiveness, impact, scalability, and equity in treating and preventing HIV.

National PrEP Program M&E Implementation Guide, 2022

As Zambia progresses and expands its HIV prevention services and health systems, it is vital to track corresponding data so that the health system can be adjusted as needed. This guide provides information on how to monitor and evaluate data from the HIV prevention services health system in Zambia.
Document

Zambia National HIV/AIDS Communication & Advocacy Strategy, 2019-23

With the Government of the Republic of Zambia embarking on a program for health promotion, a National HIV/AIDS Communication & Advocacy Strategy will serve to target different populations through methods most effective in reaching them. This Strategy will also work with key implementing stakeholders in designing effective social and behavioral programs for comprehensive HIV care…
Document

Zambia HIV Prevention Volunteer AGYW Training Manual, 2017

Zambia’s HIV Prevention Volunteer AGYW Training Manual is primarily designed to train USAID Zambia Community HIV Prevention Project (USAID-CHPP) HIV Prevention volunteers. This training will guide volunteers on how to collect necessary information from their communities about where HIV care is needed and how best to make such care accessible.
Document

Zambia Private Health Sector Analysis SRH & HIV, 2019

The Government of the Republic of Zambia seeks to foster private sector development in health, with a focus on sexual reproductive health (SRH) and HIV. This analysis lays out the opportunities and recommendations regarding how private sector can be leveraged to offer equitable, sustainable, and accessible care through a healthy total market.
Document

Digital Health Landscaping Report

This landscape analysis aimed to identify common virtual channels used in several countries, estimate the number of users of each channel, and categorize countries into one of three groups based on potential for interventions to use virtual channels to succeed. Users were defined as adolescent girls and young women (aged 15–24), pregnant or breastfeeding people…
Document

Zambia COP, 2022

The goal of Zambia’s 2022 Country Operational Plan is to maintain progress from 2021 in key areas related to health promotion such as refining efforts to eliminate policy barriers, insitutionalizing client- centered services, helping the country achieve 95-95-95, and spotlighting HIV prevention and treatment access for all populations in need.
Document

Zambia Activation Session for Youth-focused HIV Prevention Programming

In collaboration with the Ministry of Health and National AIDS Council of the Government of the Republic of Zambia, MOSAIC convened the country’s first Activation Session for Youth-focused HIV Prevention Programming in Lusaka in July 2022. The session focused on challenges and potential solutions for interventions engaging adolescent girls and young women and their parents…
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