Gilead's Truvada (TDF/FTC) registrationUnder review
Generic versions of TDF/FTC for preventionApproved
Types of Delivery Projects
- Clinical trial
- Demonstration projects, which road-test the use of new options in real-world settings—not in a trial site. They have a formal evaluation component that is designed to address specific elements of introduction such as infrastructure needs and ways individuals can integrate it into daily activities.
- Large-scale implementation initiative — funded/implementer involvement and investment in some or all steps related to comprehensive introduction that may or may not use government clinics as the primary service delivery point – e.g., Kenya’s Jilinde program.
- National level — PrEP availability in government clinics.
- Product introduction and support projects
Research, Demonstration and Implementation Projects
- Consolidated Guidelines for Prevention and Treatment of HIV in Uganda (2016)
- National HIV AND AIDS Strategic Plan 2015/2016 – 2019/2020
- The Bill & Melinda Gates Foundation
- IMPAACT Network
- Microbicide Trials Network (MTN)
- National Institute of Allergy and Infectious Diseases (NIAID)
- National Institutes of Health (NIH)
- National Institute of Mental Health (NIMH)
- National Institute of Child Health and Human Development (NICHD)
- Nike Foundation
- International Partnership for Microbicides (IPM)
- Ugand Ministry of Health
- United States Agency for International Development (USAID)
PrEP provides an effective additional biomedical prevention option for HIV-negative people at substantial risk of acquiring HIV infection. These include people who:
- Have multiple sexual partners
- Engage in transactional sex including sex workers
- Use or abuse injectable drugs and alcohol
- Have had more than one episode of an STI within the last twelve months
- Are part of a discordant couple, especially if the HIV-positive partner is not on ART or has been on ART for less than six months
- Are recurrent users of PEP (three consecutive cycles of PEP)
- Engage in anal sex
- Are members of key populations who are unable or unwilling to achieve consistent use of condoms
These risk factors are likely to be more prevalent in populations such as sex workers, fisher folk, long-distance truck drivers, men who have sex with men (MSM), uniformed forces and adolescents and young women engaged in transactional sex.
Resources for Uganda
- Map of HIV Prevention Research and PrEP Demonstration Sites in Uganda
- SEARCH (Sustainable East Africa Research in Community Health) is an ongoing demonstration project in Uganda providing HIV testing and PrEP to at risk populations.
- Columbia University ICAP is working in Uganda to implement PrEP services for key populations.
- The IMPAACT Network is planning a study in Uganda examining PrEP adherence among HIV-uninfected pregnant adolescents and young women, comparing pregnancy outcomes among women who take PrEP and women who decline PrEP during the antenatal period.
- Ugandan Civil Society Groups – A number of AVAC alumni are involved with the vibrant coalition of Ugandan civil society groups working to articulate the need for PrEP as part of comprehensive combination prevention. Click here to learn more about their work.
- A Framework for Scaling Up PrEP can help implementers, government and advocates begin planning for and implementing PrEP programs.
- Click for the latest information from the Ugandan Ministry of Health.