Discussing Early Results from the SEARCH Dynamic Choice Study

Tuesday23April

Virtual

Join AVAC and Professor Moses Kamya of Makerere University to find out why the early results of the SEARCH Dynamic Choice study were some of the most exciting to come out of CROI in 2024.

Conducted in Kenya and Uganda, the study offered oral PrEP, PEP or injectable cabotegravir to both men and women, and an option to switch products. Prevention services were person-centered, including access to a clinician by phone at any time, clinic and community access to services, and counseling to develop personalized adherence plans. Coverage among study participants increased to 70% (compared to 13% in the standard of care), 28% of participants used two different products during the study, and the study arm ended with zero incidence of HIV compared to 1.8% in the control group. These numbers show why adding to the method mix expands the number of people who continue with prevention—even as their needs change.

The webinar will consist of a presentation by Professor Kamya, followed by a robust discussion about the role of choice in HIV prevention.

Featured Resources

Document

Coordinating Implementation Science for CAB for PrEP: Linking Modellers with the Latest Implementation Science Evidence, March 2024

This document summarises key takeaways from a March 2024 BioPIC Think Tank to ensure modellers and implementation science researchers remain aligned on the latest cabotegravir for PrEP data and evidence.

Document

Coordinating Implementation Science: Taking Stock of PrEP Evidence

This document summarises key takeaways from the BioPIC Think Tank held in March 2024 to review existing PrEP evidence and evidence gaps to date.

External Link

Equity of PrEP uptake by race, ethnicity, sex and region in the United States in the first decade of PrEP: A population-based analysis

This article from The Lancet Regional Health- Americas describes trends in PrEP uptake during the first ten years of PrEP provision in the United States by race, ethnicity, sex, and region.

External Link

Exploring Attitudes Toward Pre-Exposure Prophylaxis for HIV Prevention Prior to Implementation Among Female Sex Workers in Malaysia: Results from a qualitative study

This article from Patient Preference and Adherence describes the results of a qualitative study with female sex workers in Malaysia to assess the potential need for PrEP in this population and the factors that determine willingness to use oral PrEP.

Document

Opportunities for Pharmacist-Delivered Injectable PrEP in the USA

These Quick Take briefings from Georgetown University’s O’Neill Institute for National and Global Health Law provide insights on barriers and opportunities for pharmacist-administered injectable PrEP in the USA, including delivery via mobile pharmacies.

External Link

How Men Influence Young Women Taking PrEP: Perspectives from young women, male partners, and male peers in Siaya county, Western Kenya

This article from BMC Women’s Health describes the results of a study exploring the views of young women, male partners, and male peers of young women in Siaya County, Western Kenya, to illustrate how men influence, and can support, young women in using PrEP.

External Link

Questioning Risk Compensation: Pre-exposure prophylaxis (PrEP) and sexually transmitted infections among men who have sex with men, capital region of Denmark, 2019 to 2022

This article from Eurosurveillance describes the results of a study comparing rates for chlamydia, gonorrhoea and syphilis before and after PrEP initiation in gay and bisexual men who have sex with men in Denmark.

External Link

Uptake and Challenges with Daily Oral Pre-exposure Prophylaxis among Men who Have Sex with Men and Transgender Women, Suburban Yangon, Myanmar

This article from International Health describes PrEP uptake and 12 month retention amongst gay and bisexual men who have sex with men and transgender women in Myanmar during the covid-19 pandemic and a political crisis and includes insights into user motivations for uptake and continuation.

Presentation

HIV Post-Exposure Prophylaxis (PEP) Training

This resource, produced by the South Africa National Department of Health, is a comprehensive training on post-exposure prophylaxis (PEP) provision for health care providers.

Spreadsheet

MOSAIC – PrEP Site Implementation and New Product Readiness Assessment Tool

This tool is intended to provide insight into the current state of PrEP services and to identify critical barriers and facilitators to PrEP implementation. Additionally, this tool is designed to inform preparations for new PrEP product introduction (CAB PrEP, PrEP ring, or both) according to national priorities. Findings from readiness assessment visits using this tool…