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Maximizing Options to Advance Informed Choice for HIV Prevention (MOSAIC) is a five-year (2021-2026) global project funded by the US President’s Emergency Plan for AIDS Relief (PEPFAR) through the US Agency for International Development (USAID) to help women prevent HIV by accelerating introduction and scale-up of new and emerging biomedical prevention products.

  • For a two-page overview of MOSAIC, click here
  • For an outline of MOSAIC’s work across the product introduction framework, click here
  • To subscribe to MOSAIC’s quarterly newsletter, click here
  • Completed value chain situation analyses can be found here


Catalyzing Access to New Prevention Products to Stop HIV (CATALYST) is MOSAIC’s flagship product introduction study. The study will provide and assess an enhanced service delivery package that includes oral PrEP, PrEP ring, and injectable cabotegravir. The package of products and services for PrEP will be provided to women at PEPFAR/USAID delivery sites in Kenya, Lesotho, South Africa, Uganda, and Zimbabwe. The CATALYST study will also use quality improvement methods to refine the program and identify a core package for delivering PrEP choice. Click here for access to the protocol and study implementation materials.

More Resources

Global Tools and Resources

Value Chain Situation Analyses
Situation analyses are an initial step in supporting national planning for the introduction and scale-up of PrEP methods.

Global Acute HIV Infection Algorithm Job Aids
These job aids can assist providers in ruling out HIV infection by offering guidance through three steps: HIV testing, HIV recent exposure assessment: determining need for PEP instead of PrEP, and acute HIV infection assessment. Click here for more.

Product Registration
For an overview of the product registration process, click here.

PrEP-it 2.1
A new version of PrEP-it is now live at PrEP-it is designed to support planning, implementation, monitoring and evaluation of PrEP delivery. Key features of PrEP-it include setting national and subnational targets, estimating costs and impact associated with targets, monitoring PrEP initiation, and forecasting drug supply needs.

Template Guidelines for PrEP
These adaptable guidelines (in English and French) can be used to support the development and adoption of national guidelines that align with WHO PrEP guidance, and include prompts for national-level consideration during the guideline adaptation process. The guidelines cover daily oral PrEP, event-driven PrEP, the PrEP vaginal ring, and injectable CAB for PrEP.

HIV Prevention Ambassador Training Package and Toolkit
The HIV Prevention Ambassador Training Package and Toolkit was created to prepare potential and current PrEP users to be leaders – or “Ambassadors” – in the rollout of PrEP for HIV prevention in their communities.

HIV Prevention User Journey Tool
This tool was developed to support adolescent girls and young women to explore methods that would align with their lifestyle, needs and personal preferences; and support healthcare providers to provide informed counseling based on client needs.

Post-Exposure Prophylaxis (PEP) Policy Synthesis Brief
This brief summarizes the PEP policy landscape, how to address barriers to policy and implementation, and provides recommendations to increase PEP uptake as part of HIV prevention. While it focuses on countries within the MOSAIC consortium, the findings are broadly applicable for ministries of health, implementing partners, providers, and potential PEP users alike.

Background Resources on Cabotegravir (CAB) for PrEP
This reference document lists key resources on research and evidence for CAB for PrEP.

Building Community Acceptance for PrEP Use among Adolescent Girls and Young Women (AGYW) in Sub-Saharan Africa
These materials from a MOSAIC Action Tank held in 2022 examine which community influencers impact PrEP use among AGYW and the behavioral determinants that influence their support of AGYW PrEP use, as well as identify promising community acceptance interventions that directly address these determinants for adaptation and evaluation under MOSAIC or other PrEP-focused initiatives.

Country-Specific Analyses

PrEP ring stakeholder conversations in Eswatini, Kenya, Lesotho, Namibia, Nigeria, South Africa, Uganda, Zambia and Zimbabwe

These country-level analyses share key stakeholder perceptions of the ring in each country and are the product of consultations led by WHO, IPM, and MOSAIC during the period December 2021 – March 2022.

In 2022, MOSAIC held an action tank in Zambia called Building Community Acceptance for PrEP Use among Adolescent Girls and Young Women in Sub-Saharan Africa. Click here to view the materials that emerged from those discussions.

Click here to view a report summarizing end-user perspectives on CAB for PrEP in Eswatini.

Demand Generation

Eswatini Dapivirine Ring Messaging & Positioning Report
The Busara Centre for Behavioral Economics carried out market research on communication strategies for the PrEP ring in Eswatini in partnership with IPM and FHI 360 in 2021-2022. The resulting report recommends 12 communication strategies for positioning the PrEP ring in Eswatini, along with a description of the Eswatini context and population segments likely to take up the ring.

PrEP Category Positioning Strategy
A positioning strategy is an important marketing tool intended for use by implementers who develop national communication strategies and demand generation campaigns for PrEP. Learn about and access resources related to MOSAIC’s positioning strategy for adolescent girls and young women here.

Drug Resistance Monitoring

MOSAIC HIV Drug Resistance Monitoring Program
MOSAIC’s HIV Drug Resistance (HIVDR) Monitoring Program monitors HIVDR in PrEP seroconverters in project-based and national roll-out programs in sub-Saharan Africa. The HIVDR Monitoring Toolkit can assist ministries of health, project implementers and policy makers develop HIVDR monitoring strategies and support the collection and testing of blood samples for HIVDR testing.

Gender and Youth

To learn more about MOSAIC’s Gender and Youth Strategy, click here.

The NextGen Squad
The MOSAIC NextGen Squad is a team of paid youth advocates under the age of 30 from Eswatini, Kenya, Lesotho, Namibia, Nigeria, South Africa, Uganda, Zambia, and Zimbabwe. This dynamic group of young people shape, influence, and participate in a variety of MOSAIC project activities. They ultimately hold MOSAIC accountable as the project aligns its plans, actions, monitoring and evaluation, and learning efforts to be responsive to young people’s needs, preferences, and lived experiences; include the diversity of AGYW; and meaningfully engage young people in research and research utilization.