Resource Library

Adoption of guidelines on and use of oral pre-exposure prophylaxis: a global summary and forecasting study

Widespread adoption of WHO PrEP recommendations coincided with a global increase in PrEP use. Although the 2020 global PrEP target will be missed, strong future growth in PrEP use is possible. New PrEP products could expand the PrEP user base, and, with greater expansion of oral PrEP, further adoption of WHO PrEP recommendations, and simplified…

Normative Guidance/Policies, Research, Service Delivery

Health system adaptations and considerations to facilitate optimal oral pre-exposure prophylaxis scale-up in sub-Saharan Africa

Countries in sub-Saharan Africa have progressively scaled up oral PrEP as part of combination HIV prevention. Initial scale-up efforts have generated progress, drawing lessons from existing HIV interventions, such as antiretroviral therapy and biomedical prevention. However, beset by unprepared health systems, scale-up has been slow. This review synthesises literature on essential considerations for PrEP scale-up,…

Normative Guidance/Policies, Research, Service Delivery

CHARISMA Mobile: Developing a digital resource for empowerment counseling, community health clinic model for agency in relationships and safer microbicide adherence

CHARISMA is a PEPFAR- and USAID-funded empowerment counseling intervention designed to help women use oral pre-exposure prophylaxis and other antiretroviral-based HIV prevention technologies safely and effectively by addressing dynamics of their relationships with male partners, including exposure to intimate partner violence. The intervention, designed to be delivered by lay counselors, is being adapted into a…

Research, Service Delivery

Stakeholder Conversations to Inform Delivery of New HIV Prevention Methods in South Africa

Little is known about what is needed for health care providers to ensure adequate counseling on method choice, referral mechanisms, and supportive follow-up with regards to multiple biomedical HIV prevention methods. The goal of these conversations with stakeholders in South Africa was to gain input on implementation considerations from provider and potential end-user perspectives, as…

Oral PrEP Training for Providers (French)

This modifiable training slide deck was developed with support from USAID and PEPFAR through the Meeting Targets and Maintaining Epidemic Control (EpiC) project. The materials reflect WHO guidance as of 4 April 2022 and build on lessons learned from nearly ten years of oral PrEP implementation. The training is built so that it can be…

Service Delivery

Stakeholder conversations to inform delivery of new HIV prevention methods in Zimbabwe

Little is known about what is needed for health care providers to ensure adequate counseling on method choice, referral mechanisms, and supportive follow-up with regards to multiple biomedical HIV prevention methods. The goal of these conversations with stakeholders in Zimbabwe was to gain input on implementation considerations from provider and potential end-user perspectives, as well…

Eswatini Dapivirine Ring Consultation Analysis

This PrEP ring consultation analysis can support introduction of the dapivirine vaginal ring in Eswatini and is based on several inputs, including secondary research and interviews with key stakeholders in Eswatini.

Guidelines for PrEP Ring Pilot Implementation Studies

The intent of this document is to provide adaptable guidelines for the design of Dapivirine ring pilot implementation or post-introduction operations studies to help shape national ring guidelines.

Research, Service Delivery

Step by Step Oral PrEP Liberia Guidelines, 2021

This national guide adapts WHO guidelines on oral PrEP to Liberia's local context.

Normative Guidance/Policies

HIV Testing and Injectable Cabotegravir (CAB for PrEP) Introduction: What are the implications for HIV prevention scale-up and the HIV response?

One challenge which has emerged with the introduction of CAB for PrEP is the risk of Integrase Strand Transfer Inhibitor (INSTI) resistance amongst people who acquire HIV while taking CAB as prescribed. To address emerging evidence around testing algorithms and INSTI resistance in CAB users, AVAC and WHO convened a think tank with program implementers,…

Testing