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The PrEPWatch Resource Database offers a wide range of material on the status of PrEP as an option for biomedical HIV prevention around the world. Search this database to find step-by-step guidance for rolling out PrEP, summaries of the research to date on safety, efficacy and implementation, tools to assist planning and roll out, country updates on PrEP policy and access, and lessons learned from those efforts.

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14 August 2025

New WHO Guidance on Lenacapavir for Prevention and HIV Testing for Long-Acting PrEP

This 60-minute webinar is intended for communities, providers, policy makers and advocates for PrEP, HIV prevention and HIV testing. We will provide an overview of the key takeaways and new guidance from newly released Guidelines on lenacapavir for HIV prevention and testing strategies for long-acting injectable pre-exposure prophylaxis. This is the first webinar in a…

Normative Guidance/Policies, Service Delivery, Testing

Event
24 July 2025

Southern African HIV Clinicians Society Guideline on Pre-Exposure Prophylaxis to Prevent HIV (2025)

This guideline is an update to the Southern African HIV Clinicians Society (SAHCS) 2020 recommendations on HIV PrEP. Previous SAHCS guidance was limited to the provision of oral emtricitabine/tenofovir disoproxil fumarate (F/TDF) PrEP. This update includes newer PrEP modalities, including the monthly dapivirine vaginal ring (DVR) and the long-acting cabotegravir intramuscular injection (CAB-LA). It also…

Normative Guidance/Policies

External Link
24 July 2025

South African Guidelines for the Provision of Pre-exposure Prophylaxis (PrEP) to Persons at Substantial Risk of HIV Infection- 2021 Update

These PrEP guidelines, developed by the South African National Department of Health and released in 2021, serve as an update to the 2020 national PrEP guidelines.

Normative Guidance/Policies

Document
18 July 2025

Guidelines on Lenacapavir for HIV Prevention and Testing Strategies for Long-Acting Injectable Pre-Exposure Prophylaxis

In this guideline, WHO recommends an offering long-acting injectable lenacapavir (LEN) as an additional HIV prevention choice, as part of combination HIV prevention approaches. LEN, administered twice a year as PrEP, has been shown to be highly effective at reducing the risk of HIV acquisition. In this guideline, WHO also recommends using HIV rapid diagnostic…

Normative Guidance/Policies, Testing

External Link
22 May 2025

Multipurpose Prevention Technologies for the Prevention of Unintended Pregnancy, HIV, and Other Sexually Transmitted Infections: Regulatory pathways and challenges

This article from Frontiers in Reproductive Health discusses potential regulatory pathways for multipurpose prevention technologies (MPTs).

Normative Guidance/Policies, Research

External Link
27 January 2025

Practical Approaches and Case-Based Models for Reaching Men and Boys with Integrated HIV Services

This implementation brief from WHO and UNAIDS highlights strategies to reach men with HIV services, including PrEP services, and contains practical examples and lessons learned from real-world implementation and information on how health policies have incorporated men’s health.

Normative Guidance/Policies, Service Delivery

External Link
24 January 2025

NIAID HIV Language Guide, 2024

This language guide outlines the current development in language and communication associated with the HIV field. It serves to aid stakeholders in effectively communicating about HIV and support information flow about HIV by suggesting empowering language in place of stigmatizing language.

Normative Guidance/Policies

Document
8 January 2025

Long-Acting PrEP for Key Populations: Considerations for Implementation

This document is intended for program implementers, advocates, policymakers, and other stakeholders who influence the rollout of long-acting options for pre-exposure prophylaxis (PrEP). It highlights some of the considerations for long-acting PrEP implementation for key population individuals.

Normative Guidance/Policies, Service Delivery

Document
6 January 2025

PEP Template Guidelines (English)

The intent of this document is to provide adaptable guidelines to support the development and adoption of national guidelines that align with World Health Organization (WHO) post-exposure prophylaxis (PEP) recommendations and guidance. The document includes prompts for national-level consideration during the guideline adaptation process.

Normative Guidance/Policies

Document
13 December 2024

Global Acute HIV Infection Algorithm Job Aids for Providers

This tool can assist providers in assessing acute HIV infection (AHI) in clients using oral PrEP, PrEP ring, and CAB PrEP by offering guidance through three steps: HIV testing, recent exposure to HIV assessment, and AHI assessment. Providers are encouraged to use clinical judgement and defer to national guidance as needed.

Normative Guidance/Policies

Document