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Resource Library

The PrEPWatch Resource Database offers a wide range of material on the status of PrEP as an option for biomedical HIV prevention around the world. Search this database to find step-by-step guidance for rolling out PrEP, summaries of the research to date on safety, efficacy and implementation, tools to assist planning and roll out, country updates on PrEP policy and access, and lessons learned from those efforts.

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21 November 2025

Ukraine HIV Clinical Guidelines 2025

These clinical guidelines, released by the Ukraine Ministry of Health in 2025, include the latest recommendations for HIV services, including oral PrEP and injectable cabotegravir (CAB) for PrEP.

Normative Guidance/Policies

Document
3 November 2025

Consolidated Guidelines for the Prevention and Treatment of HIV and AIDS in Uganda, 2022

These guidelines, produced in 2022 by the Uganda Ministry of Health, provide guidance on the diagnosis of HIV, the care of people living with HIV, and the use of antiretroviral drugs for treating and preventing HIV infection, including injectable cabotegravir and the dapivirine vaginal ring.

Normative Guidance/Policies

Document
3 November 2025

Malawi Service Delivery Guidelines and Standard Operating Procedures for the Provision of HIV Pre-Exposure Prophylaxis using Oral or Long-acting Injectable Options (2024)

The document, produced by the Malawi Ministry of Health, is a guideline to support funders, implementing partners, district health team leads and service providers in implementing Oral and Long-Acting Injectable PrEP in Malawi.

Normative Guidance/Policies

Document
25 September 2025

HIV Country Planning Hub

This platform, hosted by GBGMC in partnership with national civil society groups and technical collaborators, features national HIV prevention and treatment plans developed by and for communities most critical to reaching the last mile of the HIV response. Each plan reflects local priorities and community-led strategies to reach populations most affected by HIV.

Community/Advocacy, Normative Guidance/Policies

External Link
19 August 2025

Standard Operating Procedure for Injectable Lenacapavir as Pre-exposure Prophylaxis

This document, developed by the South to South Learning Network, provides an adaptable standard operating procedure (SOP) to support the development and adoption of national SOPs that align with World Health Organization recommendations and guidance on injectable lenacapavir for PrEP. Click here for a version of this resource in Word format.

Normative Guidance/Policies, Service Delivery

Document
14 August 2025

New WHO Guidance on Lenacapavir for Prevention and HIV Testing for Long-Acting PrEP

This 60-minute webinar is intended for communities, providers, policy makers and advocates for PrEP, HIV prevention and HIV testing. We will provide an overview of the key takeaways and new guidance from newly released Guidelines on lenacapavir for HIV prevention and testing strategies for long-acting injectable pre-exposure prophylaxis. This is the first webinar in a…

Normative Guidance/Policies, Service Delivery, Testing

Event
24 July 2025

Southern African HIV Clinicians Society Guideline on Pre-Exposure Prophylaxis to Prevent HIV (2025)

This guideline is an update to the Southern African HIV Clinicians Society (SAHCS) 2020 recommendations on HIV PrEP. Previous SAHCS guidance was limited to the provision of oral emtricitabine/tenofovir disoproxil fumarate (F/TDF) PrEP. This update includes newer PrEP modalities, including the monthly dapivirine vaginal ring (DVR) and the long-acting cabotegravir intramuscular injection (CAB-LA). It also…

Normative Guidance/Policies

External Link
24 July 2025

South African Guidelines for the Provision of Pre-exposure Prophylaxis (PrEP) to Persons at Substantial Risk of HIV Infection- 2021 Update

These PrEP guidelines, developed by the South African National Department of Health and released in 2021, serve as an update to the 2020 national PrEP guidelines.

Normative Guidance/Policies

Document
18 July 2025

Guidelines on Lenacapavir for HIV Prevention and Testing Strategies for Long-Acting Injectable Pre-Exposure Prophylaxis

In this guideline, WHO recommends an offering long-acting injectable lenacapavir (LEN) as an additional HIV prevention choice, as part of combination HIV prevention approaches. LEN, administered twice a year as PrEP, has been shown to be highly effective at reducing the risk of HIV acquisition. In this guideline, WHO also recommends using HIV rapid diagnostic…

Normative Guidance/Policies, Testing

External Link
22 May 2025

Multipurpose Prevention Technologies for the Prevention of Unintended Pregnancy, HIV, and Other Sexually Transmitted Infections: Regulatory pathways and challenges

This article from Frontiers in Reproductive Health discusses potential regulatory pathways for multipurpose prevention technologies (MPTs).

Normative Guidance/Policies, Research

External Link