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The PrEPWatch Resource Database offers a wide range of material on the status of PrEP as an option for biomedical HIV prevention around the world. Search this database to find step-by-step guidance for rolling out PrEP, summaries of the research to date on safety, efficacy and implementation, tools to assist planning and roll out, country updates on PrEP policy and access, and lessons learned from those efforts.

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24 July 2025

Southern African HIV Clinicians Society Guideline on Pre-Exposure Prophylaxis to Prevent HIV (2025)

This guideline is an update to the Southern African HIV Clinicians Society (SAHCS) 2020 recommendations on HIV PrEP. Previous SAHCS guidance was limited to the provision of oral emtricitabine/tenofovir disoproxil fumarate (F/TDF) PrEP. This update includes newer PrEP modalities, including the monthly dapivirine vaginal ring (DVR) and the long-acting cabotegravir intramuscular injection (CAB-LA). It also…

Normative Guidance/Policies

External Link
24 July 2025

South African Guidelines for the Provision of Pre-exposure Prophylaxis (PrEP) to Persons at Substantial Risk of HIV Infection- 2021 Update

These PrEP guidelines, developed by the South African National Department of Health and released in 2021, serve as an update to the 2020 national PrEP guidelines.

Normative Guidance/Policies

Document
18 July 2025

PEP in Africa: Prospects, opportunities, and challenges

This special JIAS supplement illustrates current PEP advances and challenges to improve the delivery and uptake of PEP across sub-Saharan Africa.

Research, Service Delivery

External Link
16 May 2025

The Impact of the PEPFAR Funding Freeze on HIV Deaths and Infections: A mathematical modelling study of seven countries in sub-Saharan Africa

This article from eClinicalMedicine estimates the impact of PEPFAR stop work orders on new HIV infections in Ethiopia, Kenya, Malawi, South Africa, Tanzania, Zambia, and Zimbabwe.

Research, Service Delivery

External Link
9 April 2025

A Mixed-Method Study of Feasibility and Acceptability of the Dapivirine Vaginal Ring among Adolescent Girls and Young Women (AGYW) in Selected Zimbabwean Districts

This article from PLOS Global Public Health describes the results of a study assessing the acceptability and feasibility of introducing the dapivirine vaginal ring (DVR) as an HIV prevention method among young women in Zimbabwe and to assess motivations and barriers of DVR uptake among the target population.

Research, Service Delivery

External Link
8 April 2025

Guidance for Developing a National Male Engagement Strategy for HIV Prevention

This guidance, produced by the South-to-South Learning Network, can help decision-makers at national level, sub-national level, and at programme level to develop a national male engagement strategy for HIV prevention. This guidance is focussed on vulnerable men who are not a member of a key population.

Community/Advocacy, Demand Creation/Marketing, Service Delivery

Document
7 April 2025

PrEP Uptake and Utilisation Among Adolescent Girls and Young Women in Sub-Saharan Africa: A scoping review

This scoping review from AIDS and Behavior maps research on PrEP delivery outside clinical trials to adolescent girls and young women in sub Saharan Africa.

Research, Service Delivery

External Link
18 March 2025

A Health Systems Approach to More Effective Decentralised HIV Prevention: Development of Malawi’s Blantyre Prevention Strategy

This article from BMJ Global Health provides background on and shares the experiences of the Blantyre Prevention Strategy (BPS), a health systems-based approach to HIV prevention that directs investments towards embedding essential functions within Blantyre City and District in Malawi. The approach includes developing district-led systems and capabilities in effective disease surveillance and data-driven targeting,…

Demand Creation/Marketing, Research, Service Delivery

External Link
14 March 2025

Developing and Introducing a Dual Prevention Pill- Oral PrEP & oral contraception for HIV and pregnancy prevention

A coalition of partners is developing a novel Dual Prevention Pill (DPP) for prevention of pregnancy and HIV acquisition in high-need countries. In East and Southern Africa — where the DPP is initially planned for introduction — 65 percent of new HIV infections are amongst women aged 15 and over, and 15 percent of women…

Community/Advocacy, Research

Document
5 March 2025

2024 Q4 Global PrEP Tracker

AVAC’s Global PrEP Tracker offers two views on PrEP uptake around the world. Visit data.prepwatch.org for a dynamic map-based tool to explore trends in oral PrEP use globally as countries introduce and scale up PrEP programs. For insights on the full scope of PrEP use around the world, the PrEP Tracker as a spreadsheet offers…

Monitoring & Evaluation

Spreadsheet