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Resource Library

The PrEPWatch Resource Database offers a wide range of material on the status of PrEP as an option for biomedical HIV prevention around the world. Search this database to find step-by-step guidance for rolling out PrEP, summaries of the research to date on safety, efficacy and implementation, tools to assist planning and roll out, country updates on PrEP policy and access, and lessons learned from those efforts.

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9 February 2026

PrEP Clinical Reporting Tools

This suite of clinical reporting forms, developed by South Africa’s National Department of Health, can be used for PrEP reporting, including injectable lenacapavir (LEN). The download folder includes forms for PrEP initiation, continuation, pregnancy outcome reporting, and seroconversion reporting.

Monitoring & Evaluation

Document
9 February 2026

Lenacapavir Training Videos

These videos, developed by South Africa’s National Department of Health, can be used to train providers offering injectable lenacapavir (LEN) for PrEP, and include modules on screening, initiation, counselling, follow-up, side effects, special considerations, and reporting.

Service Delivery

External Link
9 February 2026

Lenacapavir Implementation Planning Tool

This tool, developed by South Africa’s National Department of Health, can be used to develop action plans for facilities introducing injectable lenacapavir (LEN).

Monitoring & Evaluation, Service Delivery, Supply Chain Management

Spreadsheet
5 February 2026

GBGMC Country Profiles

These country profiles provide concise, actionable snapshots of the HIV prevention and treatment landscape for key populations across multiple countries, including: Brazil, Eswatini, France, Kenya, Malawi, Mozambique, Nigeria, the Philippines, South Africa, Uganda, Ukraine, the United States, Vietnam, Zambia, and Zimbabwe. Country profiles highlight: History of PrEP introduction Updates on PrEP Products Key population epidemiology…

Community/Advocacy, Demand Creation/Marketing, Monitoring & Evaluation, Normative Guidance/Policies, Service Delivery

External Link
12 December 2025

The Dual Prevention Pill Inspiration Guide

This Dual Prevention Pill (DPP) “inspiration guide,” developed by AVAC, is designed to equip implementers, health practitioners, public health advocates, and community leaders with the proven methods, insights, and creative strategies needed to effectively market and communicate the DPP to relevant audiences.

Demand Creation/Marketing

Document
8 December 2025

South Africa Lenacapavir Implementation Guidelines, 2025

This guideline, developed by South Africa’s National Department of Health, is intended to provide comprehensive clinical, programmatic, and operational direction for the safe, effective, and equitable rollout of lenacapavir as a long-acting injectable option for HIV PrEP in South Africa.

Normative Guidance/Policies

Document
30 September 2025

Prevention with PURPOSE

This presentation, delivered by Dr Linda-Gail Bekker at IAS 2025, provides an overview of PURPOSE 1 and 2 lenacapavir clinical trial results as well as special considerations for administration to different populations and drug-drug interactions.

Research

Presentation
25 September 2025

Empowering Women’s PrEP Choices: Qualitative Insights into Long-Acting PrEP Preferences and Decision-Making during Pregnancy and Breastfeeding in South Africa and Botswana

This article from AIDS and Behavior explores preferences for various long-acting PrEP modalities amongst pregnant and lactating people in Botswana and South Africa. It further examines participants’ HIV risk perception during pregnancy and breastfeeding, their perceived individual-level facilitators and barriers of each PrEP modality, and the support needed by participants for PrEP uptake and continuation.

Research, Service Delivery

External Link
25 September 2025

HIV Country Planning Hub

This platform, hosted by GBGMC in partnership with national civil society groups and technical collaborators, features national HIV prevention and treatment plans developed by and for communities most critical to reaching the last mile of the HIV response. Each plan reflects local priorities and community-led strategies to reach populations most affected by HIV.

Community/Advocacy, Normative Guidance/Policies

External Link
24 July 2025

Southern African HIV Clinicians Society Guideline on Pre-Exposure Prophylaxis to Prevent HIV (2025)

This guideline is an update to the Southern African HIV Clinicians Society (SAHCS) 2020 recommendations on HIV PrEP. Previous SAHCS guidance was limited to the provision of oral emtricitabine/tenofovir disoproxil fumarate (F/TDF) PrEP. This update includes newer PrEP modalities, including the monthly dapivirine vaginal ring (DVR) and the long-acting cabotegravir intramuscular injection (CAB-LA). It also…

Normative Guidance/Policies

External Link