Resource Library

Southern African HIV Clinicians Society Guideline on Pre-Exposure Prophylaxis to Prevent HIV (2025)

This guideline is an update to the Southern African HIV Clinicians Society (SAHCS) 2020 recommendations on HIV PrEP. Previous SAHCS guidance was limited to the provision of oral emtricitabine/tenofovir disoproxil fumarate (F/TDF) PrEP. This update includes newer PrEP modalities, including the monthly dapivirine vaginal ring (DVR) and the long-acting cabotegravir intramuscular injection (CAB-LA). It also…

Normative Guidance/Policies

South African Guidelines for the Provision of Pre-exposure Prophylaxis (PrEP) to Persons at Substantial Risk of HIV Infection- 2021 Update

These PrEP guidelines, developed by the South African National Department of Health and released in 2021, serve as an update to the 2020 national PrEP guidelines.

Normative Guidance/Policies

The Impact of the PEPFAR Funding Freeze on HIV Deaths and Infections: A mathematical modelling study of seven countries in sub-Saharan Africa

This article from eClinicalMedicine estimates the impact of PEPFAR stop work orders on new HIV infections in Ethiopia, Kenya, Malawi, South Africa, Tanzania, Zambia, and Zimbabwe.

Research, Service Delivery

Developing and Introducing a Dual Prevention Pill- Oral PrEP & oral contraception for HIV and pregnancy prevention

A coalition of partners is developing a novel Dual Prevention Pill (DPP) for prevention of pregnancy and HIV acquisition in high-need countries. In East and Southern Africa — where the DPP is initially planned for introduction — 65 percent of new HIV infections are amongst women aged 15 and over, and 15 percent of women…

Community/Advocacy, Research

Safety and Drug Quantification of the Dapivirine Vaginal Ring and Oral Pre-Exposure Prophylaxis in Breastfeeding Mother–Infant Pairs (MTN-043): A phase 3B, open-label, randomised trial

This article from The Lancet HIV discusses the results of the Microbicide Trials Network (MTN)-043 trial, which assessed the safety of use of the dapivirine vaginal ring during breastfeeding amongst participants in Malawi, South Africa, Uganda, and Zimbabwe.

Research

MTN-020 ASPIRE

Archived from the MTN website before it was taken down. Archived MTN ASPIRE news page available here. Primary Objectives Determine the effectiveness of dapivirine (25 mg) administered in a silicone elastomer matrix vaginal ring (VR), when inserted once every 4 weeks, in preventing HIV-1 infection among healthy sexually active HIV-uninfected women Assess the safety of…

Barriers to PrEP Use and Adherence among Adolescent Girls and Young Women in Eastern, Southern, and Western Africa: A scoping review

This article from BMC Women’s Health provides an overview of barriers to PrEP use and adherence by adolescent girls and young women across several African countries.

Research, Service Delivery

Characterizing Populations Prioritized for PrEP in 19 African Countries: A review of national guidance

This article from Journal of the International AIDS Society describes the results of a review of PrEP guidelines in 19 African countries to characterize which populations are prioritized for PrEP in Africa.

Research, Service Delivery

Twice-Yearly Lenacapavir for HIV Prevention in Men and Gender-Diverse Persons

This article from the New England Journal of Medicine describes the results of PURPOSE 2, the Phase III clinical trial for injectable lenacapavir for PrEP, carried out amongst gay and bisexual men who have sex with men, trans men, trans women, and gender non binary individuals in Argentina, Brazil, Mexico, Peru, South Africa, Thailand, and…

Research

Initiation and Continued Use of Oral Pre-Exposure Prophylaxis among Pregnant and Postpartum Women in South Africa (PrEP-PP): A demonstration cohort study

This article from The Lancet HIV describes the results of a demonstration study in South Africa, PrEP-PP, to integrate oral PrEP provision into public clinics offering antenatal and postnatal care to pregnant and lactating people.

Research, Service Delivery