The PrEPWatch Resource Database offers a wide range of material on the status of PrEP as an option for biomedical HIV prevention around the world. Search this database to find step-by-step guidance for rolling out PrEP, summaries of the research to date on safety, efficacy and implementation, tools to assist planning and roll out, country updates on PrEP policy and access, and lessons learned from those efforts.
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Quality Improvement Brief
The Quality Improvement Collaborative (QIC) is a component of the CATALYST study that refines and makes context-specific improvements to the enhanced service delivery package to make it scalable for delivering PrEP choice. The QIC’s multi-country design enables rich learning and problem-solving by providing QI faculty, advisors, coaches, and teams from all CATALYST countries opportunities to…
Monitoring & Evaluation
Insights Report: Communicating the PrEP Category to AGYW
PrEP Category Positioning Market Research Validation Insights from Kenya, South Africa, and Zimbabwe This report is a comprehensive look at what was learned through validating the positioning direction. It explains the methodology, outlines country-specific reactions to the positioning direction, and distills key findings that were leveraged to adjust and refine the positioning to honor the…
Journal of Adolescent Health Special Issue: Lessons Learned in Providing PrEP for HIV for Adolescents and Young People at Scale
This special supplement of the Journal of Adolescent Health combines 11 scientific articles and two commentaries highlighting PrEP implementation studies among Brazil and South Africa adolescents and youth. These articles highlight the unique HIV vulnerabilities and PrEP barriers experienced by youth in these countries and the implementation strategies required to address these barriers. Five articles…
Efficacy and Safety of Long-Acting Cabotegravir Compared with Daily Oral Tenofovir Disoproxil Fumarate Plus Emtricitabine to Prevent HIV Infection in Cisgender Men and Transgender Women who Have Sex with Men 1 Year after Study Unblinding: A secondary analysis of the phase 2b and 3 HPTN 083 randomised controlled trial
This article from The Lancet HIV describes findings from the first unblinded year of the HIV Prevention Trials Network (HPTN) 083 study, which compared safety and efficacy of cabotegravir and tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) as HIV prevention for transgender women and men who have sex with men in Argentina, Brazil, Peru, South Africa, Thailand, the…
How Might We Motivate Uptake of the Dual Prevention Pill? Findings from human-centered design research with potential end users, male partners, and healthcare providers
This article from Frontiers in Reproductive Health describes the results of a study to identify barriers and motivators for Dual Prevention Pill (DPP) uptake to inform the development of a DPP demand generation strategy and broader introduction efforts for Multipurpose Prevention Technologies.
Adherence, Safety, and Choice of the Monthly Dapivirine Vaginal Ring or Oral Emtricitabine Plus Tenofovir Disoproxil Fumarate for HIV Pre-exposure Prophylaxis among African Adolescent Girls and Young Women: A randomised, open-label, crossover trial
This article from the Lancet HIV assesses product adherence, safety, and choice of oral PrEP compared with the dapivirine ring among adolescent girls and young women in South Africa, Uganda, and Zimbabwe.
South Africa PrEP Implementation Study Mapping Analysis
This analysis aims to investigate which questions will/will not be addressed by the current slate of ongoing or planned implementation science to inform decisions about investments in additional research (if needed) and provide an understanding of when insights across key questions will become available to help inform the rollout planning for the new PrEP methods…
Measuring Effects of Counseling to Increase Pre-Exposure Prophylaxis Adherence and Partner Support in South Africa Using the Healthy Relationship Assessment Tool
This article from Global Health: Science and Practice describes the results of a study to investigate the impact of the Healthy Relationships Tool, part of the CHARISMA Toolkit, on PrEP adherence amongst women in Johannesburg, South Africa.
PrEP Ring Value Chain Situation Analysis – South Africa – 2021
This value chain situation analysis can support the introduction of the dapivirine ring in South Africa across two dimensions: considering and prioritizing delivery channels for the ring, and identifying critical steps for ring introduction, including opportunities to build on the introduction and scale-up of oral PrEP.
Normative Guidance/Policies, Service Delivery
Efficacy, Safety, Tolerability, and Pharmacokinetics of Long-acting Injectable Cabotegravir for HIV Pre-exposure Prophylaxis in Transgender Women: A secondary analysis of the HPTN 083 trial
This article from the Lancet HIV discusses the results of a secondary analysis of data from the HPTN 083 trial of cabotegravir for PrEP, looking specifically at the cohort of transgender women included in the study.