Resource Library

Developing and Introducing a Dual Prevention Pill- Oral PrEP & oral contraception for HIV and pregnancy prevention

A coalition of partners is developing a novel Dual Prevention Pill (DPP) for prevention of pregnancy and HIV acquisition in high-need countries. In East and Southern Africa — where the DPP is initially planned for introduction — 65 percent of new HIV infections are amongst women aged 15 and over, and 15 percent of women…

Community/Advocacy, Research

Safety and Drug Quantification of the Dapivirine Vaginal Ring and Oral Pre-Exposure Prophylaxis in Breastfeeding Mother–Infant Pairs (MTN-043): A phase 3B, open-label, randomised trial

This article from The Lancet HIV discusses the results of the Microbicide Trials Network (MTN)-043 trial, which assessed the safety of use of the dapivirine vaginal ring during breastfeeding amongst participants in Malawi, South Africa, Uganda, and Zimbabwe.

Research

MTN-020 ASPIRE

Archived from the MTN website before it was taken down. Archived MTN ASPIRE news page available here. Primary Objectives Determine the effectiveness of dapivirine (25 mg) administered in a silicone elastomer matrix vaginal ring (VR), when inserted once every 4 weeks, in preventing HIV-1 infection among healthy sexually active HIV-uninfected women Assess the safety of…

Barriers to PrEP Use and Adherence among Adolescent Girls and Young Women in Eastern, Southern, and Western Africa: A scoping review

This article from BMC Women’s Health provides an overview of barriers to PrEP use and adherence by adolescent girls and young women across several African countries.

Research, Service Delivery

Characterizing Populations Prioritized for PrEP in 19 African Countries: A review of national guidance

This article from Journal of the International AIDS Society describes the results of a review of PrEP guidelines in 19 African countries to characterize which populations are prioritized for PrEP in Africa.

Research, Service Delivery

Twice-Yearly Lenacapavir for HIV Prevention in Men and Gender-Diverse Persons

This article from the New England Journal of Medicine describes the results of PURPOSE 2, the Phase III clinical trial for injectable lenacapavir for PrEP, carried out amongst gay and bisexual men who have sex with men, trans men, trans women, and gender non binary individuals in Argentina, Brazil, Mexico, Peru, South Africa, Thailand, and…

Research

Initiation and Continued Use of Oral Pre-Exposure Prophylaxis among Pregnant and Postpartum Women in South Africa (PrEP-PP): A demonstration cohort study

This article from The Lancet HIV describes the results of a demonstration study in South Africa, PrEP-PP, to integrate oral PrEP provision into public clinics offering antenatal and postnatal care to pregnant and lactating people.

Research, Service Delivery

True Choice in HIV Prevention Involves More than Product Options: Novel strategies in service delivery

Video Recording and English Audio / Portuguese Audio / Spanish Audio / Ukrainian Audio / Slides / Resources Join The Choice Agenda and presenters from Brazil, Kenya, and South Africa to discuss novel strategies for the delivery of HIV prevention interventions. All HIV prevention products have their “Achilles Heels.” Differentiated service delivery supports reaching a…

Service Delivery

Applying CFIR to Assess Multi-level Barriers to PrEP Delivery in Rural South Africa: Processes, gaps and opportunities for service delivery of current and future PrEP modalities

This article from Social Science and Medicine uses the Consolidated Framework for Implementation Research (CFIR) to assess the context of PrEP delivery for adolescent girls and young women (AGYW) in rural South Africa and identify the factors supporting and impeding PrEP implementation to develop strategies to improve PrEP delivery.

Research, Service Delivery

CAB PrEP Introduction Situation Analysis – South Africa – 2024

This document summarizes findings from the national situation analysis that can support the creation of a national biomedical HIV prevention platform.