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Resource Library

The PrEPWatch Resource Database offers a wide range of material on the status of PrEP as an option for biomedical HIV prevention around the world. Search this database to find step-by-step guidance for rolling out PrEP, summaries of the research to date on safety, efficacy and implementation, tools to assist planning and roll out, country updates on PrEP policy and access, and lessons learned from those efforts.

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25 September 2025

HIV Country Planning Hub

This platform, hosted by GBGMC in partnership with national civil society groups and technical collaborators, features national HIV prevention and treatment plans developed by and for communities most critical to reaching the last mile of the HIV response. Each plan reflects local priorities and community-led strategies to reach populations most affected by HIV.

Community/Advocacy, Normative Guidance/Policies

External Link
1 September 2025

Global Forecast of Long-Acting PrEP Need for Key Populations (2025–2030)

Developed by AVAC, Avenir, and Global Black Gay Men Connect, this first-of-its-kind PrEP needs forecast estimates: 11.16 million person-years of PrEP needed annually by 2030 among men who have sex with men, transgender women, female sex workers, and people who inject drugs Uptake scenarios for cabotegravir, lenacapavir, and oral monthly PrEP Forecasts segmented by region,…

Research

External Link
19 August 2025

Standard Operating Procedure for Injectable Lenacapavir as Pre-exposure Prophylaxis

This document, developed by the South to South Learning Network, provides an adaptable standard operating procedure (SOP) to support the development and adoption of national SOPs that align with World Health Organization recommendations and guidance on injectable lenacapavir for PrEP. Click here for a version of this resource in Word format.

Normative Guidance/Policies, Service Delivery

Document
18 July 2025

Long-Acting PrEP Market Assessment for Key Populations: Global access and readiness report (2025)

This market assessment supports countries, donors, implementing partners, and advocates in making informed decisions about the introduction, scale-up, and equitable delivery of long-acting PrEP among key populations and other priority groups.

Research

External Link
18 July 2025

Guidelines on Lenacapavir for HIV Prevention and Testing Strategies for Long-Acting Injectable Pre-Exposure Prophylaxis

In this guideline, WHO recommends an offering long-acting injectable lenacapavir (LEN) as an additional HIV prevention choice, as part of combination HIV prevention approaches. LEN, administered twice a year as PrEP, has been shown to be highly effective at reducing the risk of HIV acquisition. In this guideline, WHO also recommends using HIV rapid diagnostic…

Normative Guidance/Policies, Testing

External Link
18 July 2025

AIDS, Crisis, and the Power to Transform- UNAIDS 2025 Global Update

This report from UNAIDS, released in July 2025, highlights the impact that the sudden, large-scale funding cuts from international donors are having on countries most affected by HIV and showcases some inspiring examples of resilience, with countries and communities stepping up in the face of adversity to protect the gains made and drive the HIV…

Research, Service Delivery

External Link
11 June 2025

Lessons from the Field: ​​Getting PrEP Rollout Right This Time

Thirteen years after oral PrEP’s introduction, global uptake remains slow, with just over 9 million initiations—falling short of UNAIDS’ 2025 targets. While HIV infections are declining in some regions, others are experiencing increasing epidemics. Despite challenges, lessons from oral PrEP and CAB rollout have strengthened health systems for scaling up longer-acting PrEP. AVAC undertook a…

Demand Creation/Marketing, Research

Document
8 April 2025

Guidance for Developing a National Male Engagement Strategy for HIV Prevention

This guidance, produced by the South-to-South Learning Network, can help decision-makers at national level, sub-national level, and at programme level to develop a national male engagement strategy for HIV prevention. This guidance is focussed on vulnerable men who are not a member of a key population.

Community/Advocacy, Demand Creation/Marketing, Service Delivery

Document
18 March 2025

Frozen Out: Impact of the PEPFAR funding freeze on programs for key populations

This report, developed by Global Black Gay Men Connect (GBGMC) and amfAR, analyses the impact of PEPFAR funding freezes on key populations worldwide, and provides recommendations on a way forward. For live tracking of this impact, see GBGMC’s Tracking the Freeze: Real-Time Impact on Key Populations.

Community/Advocacy, Financing & Costing, Research, Service Delivery

External Link
17 February 2025

What Effect are HIV Programmes Having in Africa? A quick guide

This guide, developed by the HIV Modelling Consortium, shows the impact of HIV programmes, including PrEP programmes, on the HIV epidemic in Africa, including the impact of stopping those interventions. This guide includes an accompanying video explanation.

Monitoring & Evaluation, Research, Service Delivery

Document