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The PrEPWatch Resource Database offers a wide range of material on the status of PrEP as an option for biomedical HIV prevention around the world. Search this database to find step-by-step guidance for rolling out PrEP, summaries of the research to date on safety, efficacy and implementation, tools to assist planning and roll out, country updates on PrEP policy and access, and lessons learned from those efforts.

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21 July 2025

PrEP Implementation: What’s worked and what are we learning

Pre-exposure prophylaxis (PrEP) has emerged as a critical tool in the global HIV prevention response. Despite its proven efficacy, global uptake of oral PrEP has been slower than anticipated, falling short of UNAIDS’ 2025 targets. However, several countries have successfully scaled up oral PrEP, and in the process learnt significant lessons, many of which they…

Demand Creation/Marketing, Monitoring & Evaluation, Research, Service Delivery, Supply Chain Management

Event
18 July 2025

Long-Acting PrEP Market Assessment for Key Populations: Global access and readiness report (2025)

This market assessment supports countries, donors, implementing partners, and advocates in making informed decisions about the introduction, scale-up, and equitable delivery of long-acting PrEP among key populations and other priority groups.

Research

External Link
18 July 2025

Global Forecast of Long-Acting PrEP Need for Key Populations (2025–2030)

This first-of-its-kind forecast estimates: 11.16 million person-years of PrEP needed annually by 2030 among MSM, TGW, FSW, and PWID Uptake scenarios for CAB-LA, LEN, and oral monthly PrEP Forecasts segmented by region, population group, and product Use it to guide: Procurement planning, donor alignment, and national scale-up targets.

Research

External Link
18 July 2025

Differentiated Service Delivery: Beyond HIV treatment for integration and other health needs

This special JIAS supplement showcases evidence to advance the scale-up of differentiated service delivery beyond HIV treatment, including for HIV prevention services.

Research, Service Delivery

External Link
18 July 2025

Expanding Access to a Choice-Based HIV Prevention Market

This special JIAS supplement illustrates current evidence, implementation learnings and challenges associated with the introduction, uptake, and continued use of PrEP within the context of an expanded HIV prevention method-mix.

Research, Service Delivery

External Link
18 July 2025

PEP in Africa: Prospects, opportunities, and challenges

This special JIAS supplement illustrates current PEP advances and challenges to improve the delivery and uptake of PEP across sub-Saharan Africa.

Research, Service Delivery

External Link
18 July 2025

AIDS, Crisis, and the Power to Transform- UNAIDS 2025 Global Update

This report from UNAIDS, released in July 2025, highlights the impact that the sudden, large-scale funding cuts from international donors are having on countries most affected by HIV and showcases some inspiring examples of resilience, with countries and communities stepping up in the face of adversity to protect the gains made and drive the HIV…

Research, Service Delivery

External Link
11 June 2025

Lessons from the Field: ​​Getting PrEP Rollout Right This Time

Thirteen years after oral PrEP’s introduction, global uptake remains slow, with just over 9 million initiations—falling short of UNAIDS’ 2025 targets. While HIV infections are declining in some regions, others are experiencing increasing epidemics. Despite challenges, lessons from oral PrEP and CAB rollout have strengthened health systems for scaling up longer-acting PrEP. AVAC undertook a…

Demand Creation/Marketing, Research

Document
22 May 2025

Multipurpose Prevention Technologies for the Prevention of Unintended Pregnancy, HIV, and Other Sexually Transmitted Infections: Regulatory pathways and challenges

This article from Frontiers in Reproductive Health discusses potential regulatory pathways for multipurpose prevention technologies (MPTs).

Normative Guidance/Policies, Research

External Link
19 May 2025

The Scientific Journey of Lenacapavir: From basic science to clinical development to impact

Join us for the compelling story of the development of lenacapavir and the critical role of US support. Wes Sundquist, from the University of Utah, will share the story of capsid inhibitor discovery; and Linda-Gail Bekker, from the Desmond Tutu HIV Foundation, will discuss the critical role of South Africa in clinical development; all of…

Research

Event