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In this article, the authors describe the conceptual design of the Jilinde project, which implemented oral PrEP as a routine service at a public health scale in Kenya. The authors describe the overlapping domains of supply, demand, and government and community ownership, which combine to produce a learning laboratory environment to explore the scale-up of PrEP. The article offers critical lessons on an implementation model for scaling up oral PrEP in low- and middle-income countries.

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