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Oral pre-exposure prophylaxis (PrEP) clients may choose to stop and restart oral PrEP due to factors such as changes in perceived personal exposure to HIV, the behaviors of a sexual or injecting drug partner, the burden of taking a daily pill, side effects, and mobility. Oral PrEP programs should counsel patients on how to safely stop oral PrEP as well as how to restart. This document outlines what oral PrEP programs could offer those who choose to stop and restart.

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