Resource Library

Final Results of Open-label Study of IPM’s Dapivirine Vaginal Ring Show Increased Use and Suggest Lower Infection Rates Compared to Earlier Phase III Study

This letter from the International Partnership for Microbicides outlines the results of an open-label study on the Dapivirine Vaginal Ring

Research

Results of open-label study of a vaginal ring for HIV prevention suggest women are interested in and willing to use it

This article from the Microbicide Trials Network shares the results of an open-label study of a vaginal ring for HIV prevention

Community/Advocacy, Demand Creation/Marketing, Research

Adherence to the Dapivirine vaginal ring and oral PrEP among adolescent girls and young women in Africa: interim results from the REACH study

Adolescent girls and young women (AGYW) account for most new HIV infections in sub-Saharan Africa. WHO has endorsed oral PrEP and dapivirine vaginal ring (ring) for women at substantial risk of HIV infection. However, adherence to both products was lower among younger women in randomized placebo-controlled trials. The authors of this article assessed interim safety,…

Research

Microbicide Trials Network-042 – DELIVER Study

Microbicide Trials Network-042/DELIVER is a Phase IIIb open-label study designed to evaluate the safety and acceptability of the monthly dapivirine vaginal ring and oral PrEP in pregnant women.

Research

Barriers to Provision HIV Biomedical Prevention Services in sub-Saharan Africa

AVAC conducted a desk review of the HIV prevention policy landscape in eight countries in sub-Saharan Africa. This analysis includes: training requirements for provision of PrEP and contraceptives; clinical guidelines; National Strategic Plans for HIV and Sexual and Reproductive Health; implementation strategies; national policies on age of consent and the criminality of same-sex relationships; in-depth…

Normative Guidance/Policies, Research

CHARISMA Mobile: Developing a digital resource for empowerment counseling, community health clinic model for agency in relationships and safer microbicide adherence

CHARISMA is a PEPFAR- and USAID-funded empowerment counseling intervention designed to help women use oral pre-exposure prophylaxis and other antiretroviral-based HIV prevention technologies safely and effectively by addressing dynamics of their relationships with male partners, including exposure to intimate partner violence. The intervention, designed to be delivered by lay counselors, is being adapted into a…

Research, Service Delivery

Stakeholder Conversations to Inform Delivery of New HIV Prevention Methods in South Africa

Little is known about what is needed for health care providers to ensure adequate counseling on method choice, referral mechanisms, and supportive follow-up with regards to multiple biomedical HIV prevention methods. The goal of these conversations with stakeholders in South Africa was to gain input on implementation considerations from provider and potential end-user perspectives, as…

AGYW from Kenya and South Africa: The POWER demonstration project

This poster outlines results from the POWER demonstration project, including characterizing young women who initiate PrEP in Kenya and South Africa, determining PrEP persistence and patterns of use, assessing HIV incidence and drug resistance among PrEP seroconverters, and evaluating different PrEP delivery models.

Research, Service Delivery

MyPrEP Decision Support Tool Increases PrEP Persistence in AGYW Attending an Urban Primary Health Care Clinic in South Africa

A poster presented at HIVR4P 2021 explored the effectiveness of digital tools presented at primary care clinics in South Africa at increasing PrEP adherence.

Research

AGYW’s PrEP-user Journey During an Implementation Science Study in South Africa and Kenya

Journal article appearing in PLOS ONE examining adolescent girls and young women's experience with oral PrEP in South Africa and Kenya. PrEP uptake was facilitated when offered as part of an integrated sexual reproductive health service, but hampered by low awareness, stigma and misconceptions about PrEP in the community.

Research