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The PrEPWatch Resource Database offers a wide range of material on the status of PrEP as an option for biomedical HIV prevention around the world. Search this database to find step-by-step guidance for rolling out PrEP, summaries of the research to date on safety, efficacy and implementation, tools to assist planning and roll out, country updates on PrEP policy and access, and lessons learned from those efforts.

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13 January 2023

Differentiated HIV Services for Transgender People in Four South African Districts: Population characteristics and HIV care cascade

This article from the Journal of the International AIDS Society describes a differentiated service delivery model across four South African sites and transgender individuals who access these services. It assesses whether hormone therapy is associated with continued use of PrEP and viral load suppression.

Research, Service Delivery

External Link
21 December 2022

Adherence Challenges with Daily Oral Pre-exposure Prophylaxis during Pregnancy and the Postpartum Period in South African Women: A cohort study

This article from the Journal of the International AIDS Society explores pharmacologic measures of PrEP adherence during pregnancy and postpartum and the factors related to optimal adherence during periods of sexual activity in this population.

Research

External Link
21 December 2022

End-user Research in Support of Long-acting Systemic Antiretroviral Delivery Systems: Insights from qualitative research with providers and target users in South Africa

This article from BMC Infectious Diseases describes qualitative research investigating perceptions of and preferences for a long-acting, biodegradable implantable PrEP product designed to address challenges relating to adhering to a daily pill regimen amongst adolescent girls and young women and sex workers in Guateng Province, South Africa.

Research

External Link
5 December 2022

Characterizing the Impact of the COVID-19 Pandemic on HIV PrEP care: A review and synthesis of the literature

This review from the journal AIDS and Behavior provides an examination of the influences of the COVID-19 pandemic on engagement in the PrEP care continuum, and looks at the barriers and facilitators to PrEP uptake during this time.

Research, Service Delivery

External Link
5 December 2022

PrEP Among Pregnant and Lactating People in 18 PEPFAR-Supported Countries: A review of HIV strategies and guidelines

This article from Global Health: Science and Practice examines the evolution of strategies and guidance on PrEP services for pregnant and lactating people from 18 countries supported by the U.S. President’s Emergency Plan for AIDS Relief (PEPFAR).

Normative Guidance/Policies, Research

External Link
18 November 2022

Transgender Women in HPTN 083: An evaluation of safety, efficacy, and gender affirming hormonal therapy interactions with long-acting cabotegravir

This poster from AIDS 2022 presents an analysis of results from the HPTN 083 study, looking at the impact of feminizing gender affirming hormones on cabotegravir (CAB) for PrEP pharmacokinetics.

Research

Document
15 November 2022

Results from a Safety Study of the Dapivirine Vaginal Ring and Oral PrEP in Breastfeeding Mother-Infant Pairs

This poster from AIDS 2022 presents results from the MTN-043/B-Protected trial, comparing the safety profile of the dapivirine vaginal ring against oral PrEP use during breastfeeding.

Research

Document
14 November 2022

Uptake and Use of Oral PrEP among Heterosexual Men: Results and lessons from a pilot study in Johannesburg, South Africa

Although most PrEP strategies and programs have focused on other populations, formative research conducted by the Mpilo Project in South Africa found that PrEP may also be beneficial and appealing to a substantial segment of heterosexual men. From August 2021 to July 2022 the project implemented a pilot study providing PrEP to 564 men, free…

Research, Service Delivery

Event
10 November 2022

Relative Cost-effectiveness of Long-acting Injectable Cabotegravir versus Oral Pre-exposure Prophylaxis in South Africa based on the HPTN 083 and HPTN 084 Trials: A modelled economic evaluation and threshold analysis

This article from The Lancet HIV estimates the incremental cost-effectiveness of long-acting injectable cabotegravir (CAB for PrEP) compared with tenofovir disoproxil fumarate and emtricitabine (TDF/FTC oral PrEP) in South Africa, using methods standard to government planning, and determines the threshold price at which CAB for PrEP is as cost-effective as TDF/FTC oral PrEP.

Financing & Costing, Research

External Link
4 November 2022

South Africa COP, 2022

The goal of South Africa’s 2022 Country Operational Plan is to maintain progress from 2021 in key areas related to health promotion such as refining efforts to eliminate policy barriers, insitutionalizing client- centered services, helping the country achieve 95-95-95, and spotlighting HIV prevention and treatment access for all populations in need.

Normative Guidance/Policies

Document