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The PrEPWatch Resource Database offers a wide range of material on the status of PrEP as an option for biomedical HIV prevention around the world. Search this database to find step-by-step guidance for rolling out PrEP, summaries of the research to date on safety, efficacy and implementation, tools to assist planning and roll out, country updates on PrEP policy and access, and lessons learned from those efforts.

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27 February 2023

Impact and Cost-effectiveness of the National Scale-up of HIV Pre-exposure Prophylaxis among Female Sex Workers in South Africa: A modelling analysis

This article from the Journal of the International AIDS Society evaluates the impact and cost-effectiveness of South Africa’s national PrEP programme for female sex workers.

Financing & Costing, Research, Service Delivery

External Link
15 February 2023

Incorporating End-users’ Voices into the Development of an Implant for HIV Prevention: A discrete choice experiment in South Africa and Zimbabwe

This article from BMC Women’s Health describes the results of a discrete choice experiment undertaken with adolescent girls and young women in South Africa and Zimbabwe where participants were asked their preferences for a hypothetical HIV prevention implant.

Research

External Link
10 February 2023

PrEPVacc Study

The PrEPVacc trial, taking place in Mozambique, South Africa, Tanzania, and Uganda from 2018 to 2024, combines an evaluation of experimental HIV vaccines and oral PrEP at the same time. The PrEP arm of the trial compares the effectiveness of TDF/FTC (Truvada) with F/TAF (Descovy).

Research

External Link
6 February 2023

Pregnancy and Neonatal Safety Outcomes of Timing of Initiation of Daily Oral Tenofovir Disoproxil Fumarate and Emtricitabine Pre-exposure Prophylaxis for HIV Prevention (CAP016): An open-label, randomised, non-inferiority trial

This article from The Lancet HIV describes the results of a trial to compare pregnancy and neonatal outcomes in women exposed and not exposed to oral PrEP (TDF/FTC) during pregnancy in Durban, South Africa.

Research

External Link
13 January 2023

Differentiated HIV Services for Transgender People in Four South African Districts: Population characteristics and HIV care cascade

This article from the Journal of the International AIDS Society describes a differentiated service delivery model across four South African sites and transgender individuals who access these services. It assesses whether hormone therapy is associated with continued use of PrEP and viral load suppression.

Research, Service Delivery

External Link
21 December 2022

Adherence Challenges with Daily Oral Pre-exposure Prophylaxis during Pregnancy and the Postpartum Period in South African Women: A cohort study

This article from the Journal of the International AIDS Society explores pharmacologic measures of PrEP adherence during pregnancy and postpartum and the factors related to optimal adherence during periods of sexual activity in this population.

Research

External Link
21 December 2022

End-user Research in Support of Long-acting Systemic Antiretroviral Delivery Systems: Insights from qualitative research with providers and target users in South Africa

This article from BMC Infectious Diseases describes qualitative research investigating perceptions of and preferences for a long-acting, biodegradable implantable PrEP product designed to address challenges relating to adhering to a daily pill regimen amongst adolescent girls and young women and sex workers in Guateng Province, South Africa.

Research

External Link
5 December 2022

Characterizing the Impact of the COVID-19 Pandemic on HIV PrEP care: A review and synthesis of the literature

This review from the journal AIDS and Behavior provides an examination of the influences of the COVID-19 pandemic on engagement in the PrEP care continuum, and looks at the barriers and facilitators to PrEP uptake during this time.

Research, Service Delivery

External Link
5 December 2022

PrEP Among Pregnant and Lactating People in 18 PEPFAR-Supported Countries: A review of HIV strategies and guidelines

This article from Global Health: Science and Practice examines the evolution of strategies and guidance on PrEP services for pregnant and lactating people from 18 countries supported by the U.S. President’s Emergency Plan for AIDS Relief (PEPFAR).

Normative Guidance/Policies, Research

External Link
18 November 2022

Transgender Women in HPTN 083: An evaluation of safety, efficacy, and gender affirming hormonal therapy interactions with long-acting cabotegravir

This poster from AIDS 2022 presents an analysis of results from the HPTN 083 study, looking at the impact of feminizing gender affirming hormones on cabotegravir (CAB) for PrEP pharmacokinetics.

Research

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