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MOSAIC HIV Drug Resistance Monitoring Program
MOSAIC’s HIV Drug Resistance (HIVDR) Monitoring Program monitors HIVDR in PrEP seroconverters in project-based and national roll-out programs in sub-Saharan Africa. Activities include:
- Laboratory research to improve HIVDR testing assays and test diverse sample types for HIVDR using sensitive methods.
- Technical support and policy guidance for HIVDR assessment in seroconverters to PrEP programs.
- Implementation of HIVDR monitoring strategies in select countries in sub-Saharan Africa.
The materials below can assist ministries of health, project implementers and policy makers develop HIVDR monitoring strategies and support the collection and testing of blood samples for HIVDR testing.
Tools for HIV Drug Resistance Monitoring in PrEP Programs
Materials for Implementing Partners and Policy Makers
- HIV Drug Resistance Monitoring Protocol– An adaptable protocol template for stakeholders developing an HIVDR monitoring strategy.
- PrEP and Drug Resistance Factsheet for Policy Makers (oral PrEP)– A brief overview of the risk of HIVDR while using PrEP and implications for overall PrEP rollout.
- Monitoring and Evaluation (M&E) Plan for Drug Resistance Programs– M&E indicators for ongoing, long-term, assessment of drug resistance risk.
- Policy Brief: ART Considerations for Individuals with Recent PrEP Use– Modeling findings and implications of drug resistance with PrEP on ART.
- HIV Testing Strategies Factsheet– An overview of current point of care HIV testing methods for consideration when developing testing algorithms for PrEP programs.
- Manual of Procedures– An adaptable manual of procedures to standardize protocol implementation for HIVDR implementing partners.
Materials for Healthcare Workers
- PrEP and Drug Resistance Factsheet for Health Care Workers (oral PrEP)– A brief overview of the risk of HIVDR while using PrEP; with a focus on key counseling messages for PrEP users and health care workers.
- PrEP and Drug Resistance Training Slides– Training materials for health care workers and project implementers; topics include background on HIVDR, risk of HIVDR with PrEP, sample collection and testing, interpreting HIVDR results, and counseling considerations.
- Dried Blood Spot (DBS) Job Aid for Resistance Testing– A job aid to standardize DBS collection and shipment of samples for HIVDR testing.
- Whole Blood Collection Job Aid– A job aid to standardize whole blood collection and shipment of samples for HIVDR testing.
- Used Ring Collection Job Aid– A job aid to standardize PrEP ring collection and shipment for residual drug level testing.
- Training Video on DBS Collection– A “how-to” video that demonstrates procedures for collection and shipment of DBS samples.
- Acute Seroconversion Assessment Checklist– A clinical assessment tool for clinicians reviewing eligibility of PrEP use for clients; to limit HIVDR risk in cases of undetected infection.